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EXAM 3 STUDY SET: 3
Terms in this set (20)
Particles in a disperse system are 0.1 nm in diameter, diffuse rapidly and can pass through regular filter paper. This dispersion is a ________________.
a) molecular dispersion
b) colloidal dispersion
e) coarse dispersion
For which of the following aspects suspension dosage form would have NO advantage over solution dosage form?
a) Reduction of dose volume
b) Stability against hydrolysis
c) Taste masking
d) Depot therapy
e) Dose uniformity
Which of the following can be deduced for sedimentation of suspension preparations?
a) Larger particles show slower sedimentation.
b) Sedimentation can be increased by using a more viscous medium.
c) Lighter particles would sediment faster.
d) An increase in temperature would create faster sedimentation.
e) A denser medium would decrease the rate of sedimentation.
What will be the rate of settling in a suspension following Stokes' equation? The drug powder has a density of 2 g/ml and an average particle diameter of 3 m. The density and viscosity of the dispersion medium are 1.2 g/ml and 1.5 cp, respectively. The acceleration due to gravity is 981 cm/sec2.
a) 2.67 × 10-7 cm/sec
b) 2.62 × 10-4 cm/sec
c) 6.54 × 10-4 cm/sec
d) 4.71 × 10-3 cm/sec
e) 8.72 × 10-1 cm/sec
Which of the following methods/instruments is NOT used to prepare lyophobic colloids?
a) Colloid mills
b) Ultrasonic generators
c) Electric arc
e) Solvent changing
All of the electrical properties of colloidal systems have a common application and that is to determine the _________________ of the systems.
a) zeta potential
c) particle size
d) molecular weight
e) particle shape
The miscibility of an emulsion with water depends on the type of the emulsion. Identify the type of emulsion that is water washable?
d) Cold cream
In an emulsion, the phase in which the emulsifying agent is more soluble typically becomes the external phase. This can be best explained by ___________ theory of emulsification.
a) plastic or interfacial film theory
b) adsorption theory
c) electrical double layer theory
d) oriented-wedge theory
e) phase volume ratio theory
Which of the following statements is NOT true for rectal suppositories?
a) The pH of the rectal fluid is about neutral.
b) Drug absorption is fast and complete via rectal route due to its large surface
c) Diarrhea, tumor, and tissue dehydration may influence drug absorption.
d) Evacuant enema may increase drug absorption.
e) Blood and lymphatic vessels are present in the sub-mucosal region.
Which of the following is true for glycerinated gelatin suppositories?
a) They contain hydrogenated fatty acids.
b) The base melts faster than cocoa butter at body temperature.
c) They have to be moistened to decrease irritation.
d) They are popularly used in rectal suppositories.
e) They contain glyceryl ester of high MW fatty acids.
Which one is true for cocoa butter suppository base?
a) It contains unsaturated fatty acids such as polyethylene glycol.
b) It is popularly used in the urethral suppository.
c) Solidifying agents can be added when the melting point of coca butter is low.
d) It dissolves in the fluid of the rectum.
e) It is a macromolecule.
Which of the following is correct for nasal preparations?
a) They can deliver small volume of potent drugs.
b) Increased drug residence time is expected in the nasal cavity due to the MCC.
c) They can deliver the drugs causing epithelial irritation, inflammation, and
d) Drugs with molecular weight <100 kDa can be delivered.
e) Macromolecules cannot be delivered.
Which one is NOT true for nasal drug delivery?
a) Drug can be delivered to the brain by the nasal cavity.
b) Drug can be absorbed via active transport.
c) Drug ionization has no effect on drug absorption.
d) Nasal cavity has rich underlying vasculature.
e) Nasal cavity contains enzymes, which may digest drugs.
Which of the following statements is NOT true for pulmonary drug delivery?
a) It can bypass hepatic first-pass effect.
b) It is not suitable for every drug.
c) It shows rapid onset of action.
d) Particles less than 0.5 μm in diameter may be exhaled.
e) Pulmonary blood flow is much lower than the cardiac output.
Which one is INCORRECT for pharmaceutical aerosols?
a) Coordination is not required between actuation and inhalation if the spacer is used with MDI.
b) N2 aerosols are usually two-phase systems inside the aerosol container.
c) MDI can hold multiple doses.
d) Since solid drug particles may cause damage to the mucosa, they cannot be
delivered by pulmonary route.
e) Pressure will decrease after liquid propellant reservoir is depleted.
What type of aerosols will be usually formed if the product concentrate is emulsions?
a) Fine mist
Which of the following is an application to receive FDA approval of a new drug?
Identify isotones from the following pairs.
a) 137N and 136C
b) 8939Y and 9040Zr
c) 23592U and 23692U
d) 5828Ni and 5828Ni
e) 6229Cu and 8237Rb
A radioisotope thallous chloride sample (201Tl) with a half life of 73.1 hours contains 80 mCi radioactivity. What will be the radioactivity of the sample after 5 hours?
a) 71.7 mCi
b) 76.3 mCi
c) 83.9 mCi
d) 80.0 mCi
e) 1169.6 mCi
How would you define radiolabeling?
a) Producing radionuclide in a cyclotron
b) Treating toxicity occurred by radiopharmaceuticals
c) Incorporation of radioactive atoms into a target molecule
d) Purification of radioactive isotopes from mixture
e) Dilution of a solution containing radiotracer to a safe level
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