Upgrade to remove ads
Immunology of Aging
Terms in this set (18)
DTH response; T cell; cytokine; macrophages
Elderly patients exhibit a decreased ____. Such a decrease may result from changes in initial ____ activation, a shift in ____ production by activated cells, or altered reactivity by ____. Also, changes in the physical and chemical properties of the skin have been implicated.
Elderly patients show decreased ability for T cell proliferation.
What are the results for testing young vs elderly patients in T cell proliferative responses?
This could be a consequence of the general health of the subjects (exercise/daily activities, etc).
Although a significant age-associated decrease in proliferation of T cells (about 50%) is observed, this decrease in not observed in all studies - explain.
A set of stringent criteria for the inclusion of elderly subjects in studies evaluating the direct effects of aging on particular functions.
While it helps to control for effects of age-associated diseases, it also skews the results so that the magnitude of immuonosenescence is overestimated.
What are the advantages and disadvantages of using the Senieur Protocol for investigation of age-related functions?
Demonstrate conflicting results (same as young, less, or significantly less).
When more stringent protocol for health criteria (healthy elderly persons) were used, what were the results?
Yes, but it's not the only determining factor. Less than 10% of thymic function remains at 25.
Does thymic involution at time of puberty relate to the T cell proliferative response decrease seen in the elderly?
Did the small decline in the number of CD3+, CD4+ and CD8+ cells in elderly people correlate with the proliferative response observed?
Naive T cells to memory T cells. CD28 is also decreased, which means less co-stimulation and ultimately T cell anergy.
What T-Cell phenotype age-related change was observed? Explain what role CD28 may play in the observed changes.
IL-2; IL-2 receptors; IFN-gamma; IL-4 and IL-10; IL-6
In humans, there is a decreased production of ____, and after it was added, nothing changed, which means there was also decreased expression of ____. ____ has been reported to increase, decrease, or stay the same with age. ____ & ____ appear to increase in production with age. ____ production may increase or stay the same.
Decreased Ab production to vaccination or infection, altered Ig classes and subclasses are increased, decreased affinity of Ab, dysregulation of the anti-idiotype network, and increases in autoantibodies.
Name the 5 dysfunctions of B cell parameters associated with aging.
The proportion of NK cells in circulating lymph pool is increased in the elderly, though basal NK function shows no age-related changes.
Describe the situation of NK cell as to number and function in the elderly compared to the young.
Neutrophil and monocyte/macrophage numbers remain constant throughout life, though phagocytosis by neutrophils and macrophages declines by 50% with age in both healthy and debilitated elderly persons.
Describe any changes observed with aging of the capacity and numbers of neutrophils and macrophages.
A greater number of dendritic cells are isolated from elderly patient blood. This is thought to be due to increased compartmentalization of dendritic cells to the blood with decreased migration to peripheral organs.
Describe the changes in the distribution of dendritic cells with aging.
Decreased APC function is not explained by altered cytokine production or cell adhesion molecule expression because monocytes of young and old subjects show similar cytokine production and CAM expression.
Is age-related decreased APC function due to altered cytokine production or cell adhesion molecules expression?
Lack of T cell activation due to absence of IL-2 signals.
Age-related increase in IL-2 antagonists' production may contribute to the age-related decrease in T cell function - how?
Actin polymerization accompanying receptor-mediated responses in immune cells is absent in the elderly. Further signal transduction may be diminished due to destabilized receptor interactions through cytoplasmic tails.
Describe the changes observed in cytoskeleton function of TCR-CD3.
A higher percentage of cells from elderly individuals undergo apoptosis early after activation compared with young subjects. A larger proportion of naïve cells from the elderly undergo apoptosis than do naïve cells of young subjects.
Compare apoptosis of lymphocytes of elderly vs. the young.
THIS SET IS OFTEN IN FOLDERS WITH...
Tolerance & Autoimmunity
Overview of the Immune Response
YOU MIGHT ALSO LIKE...
Immuno Test 4
T cell Development and Effector Function
OTHER SETS BY THIS CREATOR
OTHER QUIZLET SETS
ch. 5: short-term and working memory
Maggie Jeopardy Questions Exam 1
FoBL midterm three answers