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Pharmacology Chapter 54 Drugs ONLY

Terms in this set (84)

4 classes of alkylating agents
Nitrogen mustards
Nitrosureas
Nonclassic
Platinum analogs
Example of nitrogen mustard
cyclophosphamide
Hemorrhagic cystitis is prevented by ___ in cyclophosphamide
mesna
In nonenzymatic breakdown, cyclophosphamide produces ___ and ___
acrolein and phosphoramide mustard
Adverse side effects of cyclophosphamide
Pancytopenia
GI
Alopecia
Examples of nitrosureas
Carmustine
Lomustine
T/F Nitrosureas can cross the BBB
T
Examples of nonclassic alkylating agents
procarbazine
dacarbazine
bendamustine
What is the most carcinogenic alkylating agent?
procarbazine
What is the metabolite of procarbazine?
MAOi --> critical drug:drug interactions
T/F Cyclophosphamide is a prodrug
T
MOA of cyclophosphamide
Forms DNA cross links, resulting in inhibition of DNA synthesis and function
MOA of nitrosureas (carmustine, lomustine)
Forms DNA cross links, resulting in inhibition of DNA synthesis and function
MOA of bendamustine
Forms DNA cross links, resulting in inhibition of DNA synthesis and function
MOA: methylates DNA and inhibits DNA synthesis and function
Procarbazine
Dacarbazine
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