Drugs in CNS lectures

Ketamine

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Terms in this set (5)

- Blocks the NMDA receptor
- It is a dissociative anaesthetic
- The S(+) enantiomer is used as an anti-depressant

NMDA receptor blockers

1. Ketamine
2. Memantine

- NMDA receptor blocker
- It is used in the treatment of Alzheimer's

- Anti-depressant and anxiolytic
- Acts as a partial agonist 5-HT1A receptors
- Increases 5-HT release by desensitising the 5-HT1A receptors (when these receptors are desensitised, they no longer limit 5-HT release)
- The increase in 5-HT release as anti-depressant and anxiolytic effects

- Its psychedelic effects are attributed to its binding to 5-HT2A receptor as an agonist
- This is a Gq coupled receptor
- Binds to receptor
- Causes hallucinations