Study sets, textbooks, questions
Upgrade to remove ads
Pharmacology: Absorption and Distribution
Terms in this set (54)
hydrophilic and lipophilic
What are the two different natures of the drugs?
water-loving, readily diffuse in water and tissue fluids
What are hydrophilic drugs?
fat-loving, mix well with oil based fluids
What are lipophilic drugs?
IM and SQ
How are hydrophilic drugs given?
How are lipophilic drugs given?
slows down absorption for slow release drugs
Why are some parentral drugs lipophilic?
so they dont cross to the body from GI tract; for worms
Why are some entral drugs hydrophilic?
What is the pH of the enviroment when half of the drug is ionized and half is unionized? (each drug has one)
What is the nature of the ionized drug?
What is the nature of unionized drugs?
What is happening when a drugs is designed with a pH that will cause it to be trapped in a certain environment to make it work there and not be reabsorbed back into the body?
urine, mastitic milk
What are two examples of where ion trapping occurs?
What kind of acidic antibiotics will be more ionized in mastitic milk?
What is the pH of the stomach?
What is the pH of the small intestine?
6.5- 7 neutral
What is the pH of milk?
What is the pH of the urine of carnivores?
What is the pH of the urine of herbivores?
What is the pH of blood/ bodily fluids?
A weak acid is in a basic environment, what is its nature?
A weak base is in an acidic environment, what is its nature?
A weak acid is in an acidic environment, what is its nature?
A weak base is in a basic environment, what is its nature?
An acidic drug is in the small intestine, what is its nature?
A basic drug is in the small intestine, what is its nature?
An acidic drug is in the stomach, what is its nature?
A bas is in the stomach, what is its nature?
What form of a drug absorbs the fastest?
What size particle absorbs quicker?
really tiny particles are easier to absorb
What is the concept of microionization?
shorter gi tracts
What are some enteric coated drugs useless in animals?
keep the drug from dissolving in the stomach and reacting with the acid
What is the purpose of coatings?
it will increase it
Decreased motlity of the GI tract (stasis) may affect absorption of the drugs?
it will decrease it
Increased GI motility will affect drug absorption how?
How does food in the stomach affect drug absorption?
ruminants with gi flora
How can species of the animal affect drug absorption?
slows down absorption
Vasoconstriction does what to drug absorption?
speeds up absorption
Vasodilation does what to drug absorption?
How long will Pen-G mixed with K or NA in an aqueous solution last?
How long will Pen-G mixed with Procaine suspension last?
How long will Pen-G mixed with Procaine in oil last?
How long will Pen-G mixed with Benzathine last?
CNS cappillaries lack fenestrations adn have glial cells wrapped around them making them very imperiable
What is the blood brain barrier?
age, inflammatory/injury, decreased blood pressure or shock
What 3 things affect the blood brain barrier?
What nature do drugs need to be to enter the CNS?
What age animals have a more permeable Blood brain Barrier?
What kind of drugs cross the placenta easier?
to cause birth defects
What does teratogenic mean?
What drug is prohibited for use in humans in the US because it causes flipper armed babies?
perfusion, protein binding, tissue binding
What 3 things affect the distribution of drugs?
more drugs to the area
What does increased blood flow do an area do to drug distribution?
what kind of proteins do drugs like to bind to?
Hypoalbumenamenic animals have more free or more bound drugs?
What kind of drugs are inactive, bound or free?
Sets found in the same folder
Pharmacology: Helpful Hints on Drug Names
Pharmacology Chapter 24- Drugs for Neuromuscular D…
Drugs Affecting Cholinergic Function
Sets with similar terms
Pharm ch 4
pharm chapter 1
Pharmacology wk#1 test#1
Other sets by this creator
jmsxyzPharmacology: Helpful Hints on Drug Names
Ch. 14 Drugs Affecting Cholinergic Function (PSNS)
CBC w/Clinical Implications (Intro. Ch. 34)
Pharm questions 136-180