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Pharmacology - Antidepressants

Terms in this set (44)

Antimanic, Drug Treatment for Bipolar Disorders, Mood Stabilizers, prevent or control mania, NT stabilization, inhibits excitatory NT (NE, DA), Enhances 5HT to help with depression, used for acute maina, bipolar depression. Narrow toxic range, renal elimination, 1-3 weeks to see effect, intentional tremor, weight gain, polyuria, polydipsia, interacts with OTC and caffeine, take 2 to 3 times a day, salt intake should remain constant during treatment, treating bipolar (manic-depressive) disorder, acute mania and prophylaxis of unipolar and bipolar disorder. Only mood stabilizer that has consistently shown to decrease the risk of suicide for bipolar patients, Antimanic, mood stabilizing agent. Side Effects: Drowsiness, dizziness, headache, dry mouth, thirst, GI upset, Nausea/Vomiting, fine hand tremors, hypotension, arrhythmias, pulse irregularities, polyuria, dehydration, weight gain, Alters sodium transport in nerve and muscle cells by inhibiting the phosphoinositol cascade. Its antimanic effects may be the result of increased reuptake of norepinephrine. Some say it "effects shift toward intraneuronal metabolism of catecholamines." What to know is that it affects neuronal signaling cascades, likely involving cAMP (RS), Excreted unmetabolized by kidneys, Reabsorbed by kidney in exchange for Na, Low Na levels, increased lithium reabsorption and risk of toxicity, Narrow therapeutic range = 0.5 - 1.2 mEq/L, Dose based on serum lithium levels, Monitored 2 - 3 times/week initially; maintenance q 3 months, Draw levels 12 hours after last dose, Lower doses needed for: older adults, those on diuretics, low salt diet, or with renal impairment, Adverse Effects:, Metallic taste, hand tremors, nausea, polyuria, muscle weakness, edema, weight gain, reversible leukocytosis (elevated WBC count), Elevated drug levels - vomiting, diarrhea, ataxia, dizziness, muscle twitching, Toxicity (drug levels > 2.5 mEq/L), Nystagmus, tremors, confusion, oliguria, hallucinations, convulsions