# PK final

Which model of hepatic clearance was used to derive the equation (ClH ~ Q) for high extraction ratio drugs:

A. Well-Stirred Model
B. Parallel Tube Model
C. Distributed Tube Model
D. Dispersion Model
E. Interconnected Tube Model
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The elimination rate constant of a Drug 32D was measured to be 0.372/h following intravenous injection. Using an infusion rate of 0.40 mg/min, what loading dose should be given at the start of the infusion in order to reach steady-state concentrations as quickly as possible?

A. 64.5 mg
B. 9.11 mg
C. 1.08 mg
D. 0.149 mg
E. 8.93 mg
The equation that describes the plasma drug concentration following a single oral administration in a
one-compartment open model at any time post dosing is: Equation #1

Cp = ((F x Ka x Do) / Vd(ka-k)) x (e^-kt - e^-kat)

And the equation for the terminal phase was derived as: Equation #2

Ln Cp - Ln ((F x Ka x Do) / Vd(ka-k)) - kt

During the conversion of Equation 1 into Equation 2, which term in Equation #1 approaches a value of zero drug the terminal phase?
A. e^-kat
B. -kat
C. ka
D. k E. e-kt
Following a single, oral dose, the plasma drug concentrations at one and five hours post dosing for Drug D20 were 193 μg/mL and 73 μg/mL, respectively. Using the Technique of Superposition, what is the plasma concentration at five hours post dosing, if this drug is dosed once every 4 hours?
A. 266 μg/mL
B. 193 μg/mL
C. 120 μg/mL
D. 73 μg/mL
E. 146 μg/mL
Using the trapezoidal rule, the AUC0-∞ for Drug A following a 220 mg iv injection was calculated to be 6389 μg•hr/mL. In the same subjects, the AUC0-∞ for Drug B was calculated to be 5143 μg•hr/mL for a 100 mg iv injection. The relationship between the clearance of Drug A to the clearance of Drug B is:
A. A is cleared faster than B
B. B is cleared faster than A
C. The clearance of A is the same as the clearance of B
D. Cannot be determined as the doses are different
A 345 mg intravenous injection of Canceruria A produced an initial plasma concentration of 124 µg/mL. Assuming first-order elimination kinetics and an elimination rate constant of 0.26/hr, how many half-lives will have elapsed by the time that the plasma concentration reaches 7.75 μg/mL?
A. 4 half-lives
B. 1 half-life
C. 2 half-lives
D. 3 half-lives
E. 5 half-lives
A double reciprocal plot of albumin binding data for Drug A calculated a Y-intercept of 0.20 and a slope of 1.176 x 10-6 moles/Liter. For Drug B, a similar plot yielded a Y-intercept of 0.20 and a slope of 2.22 x 10-7 moles/Liter. What is the relationship between the concentration of Albumin-Drug A complex [PDA] to the concentration of Albumin-Drug B complex [PDB] in the blood?
A. [PDA] >[PDB]
B. [PDA] <[PDB]
C. [PDA] = [PDB]