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The elimination rate constant of a Drug 32D was measured to be 0.372/h following intravenous injection. Using an infusion rate of 0.40 mg/min, what loading dose should be given at the start of the infusion in order to reach steady-state concentrations as quickly as possible?

A. 64.5 mg

B. 9.11 mg

C. 1.08 mg

D. 0.149 mg

E. 8.93 mg

A. 64.5 mg

B. 9.11 mg

C. 1.08 mg

D. 0.149 mg

E. 8.93 mg

The equation that describes the plasma drug concentration following a single oral administration in a

one-compartment open model at any time post dosing is: Equation #1

Cp = ((F x Ka x Do) / Vd(ka-k)) x (e^-kt - e^-kat)

And the equation for the terminal phase was derived as: Equation #2

Ln Cp - Ln ((F x Ka x Do) / Vd(ka-k)) - kt

During the conversion of Equation 1 into Equation 2, which term in Equation #1 approaches a value of zero drug the terminal phase?

A. e^-kat

B. -kat

C. ka

D. k E. e-kt

one-compartment open model at any time post dosing is: Equation #1

Cp = ((F x Ka x Do) / Vd(ka-k)) x (e^-kt - e^-kat)

And the equation for the terminal phase was derived as: Equation #2

Ln Cp - Ln ((F x Ka x Do) / Vd(ka-k)) - kt

During the conversion of Equation 1 into Equation 2, which term in Equation #1 approaches a value of zero drug the terminal phase?

A. e^-kat

B. -kat

C. ka

D. k E. e-kt

Following a single, oral dose, the plasma drug concentrations at one and five hours post dosing for Drug D20 were 193 μg/mL and 73 μg/mL, respectively. Using the Technique of Superposition, what is the plasma concentration at five hours post dosing, if this drug is dosed once every 4 hours?

A. 266 μg/mL

B. 193 μg/mL

C. 120 μg/mL

D. 73 μg/mL

E. 146 μg/mL

A. 266 μg/mL

B. 193 μg/mL

C. 120 μg/mL

D. 73 μg/mL

E. 146 μg/mL

Using the trapezoidal rule, the AUC0-∞ for Drug A following a 220 mg iv injection was calculated to be 6389 μg•hr/mL. In the same subjects, the AUC0-∞ for Drug B was calculated to be 5143 μg•hr/mL for a 100 mg iv injection. The relationship between the clearance of Drug A to the clearance of Drug B is:

A. A is cleared faster than B

B. B is cleared faster than A

C. The clearance of A is the same as the clearance of B

D. Cannot be determined as the doses are different

A. A is cleared faster than B

B. B is cleared faster than A

C. The clearance of A is the same as the clearance of B

D. Cannot be determined as the doses are different

A 345 mg intravenous injection of Canceruria A produced an initial plasma concentration of 124 µg/mL. Assuming first-order elimination kinetics and an elimination rate constant of 0.26/hr, how many half-lives will have elapsed by the time that the plasma concentration reaches 7.75 μg/mL?

A. 4 half-lives

B. 1 half-life

C. 2 half-lives

D. 3 half-lives

E. 5 half-lives

A. 4 half-lives

B. 1 half-life

C. 2 half-lives

D. 3 half-lives

E. 5 half-lives

A double reciprocal plot of albumin binding data for Drug A calculated a Y-intercept of 0.20 and a slope of 1.176 x 10-6 moles/Liter. For Drug B, a similar plot yielded a Y-intercept of 0.20 and a slope of 2.22 x 10-7 moles/Liter. What is the relationship between the concentration of Albumin-Drug A complex [PDA] to the concentration of Albumin-Drug B complex [PDB] in the blood?

A. [PDA] >[PDB]

B. [PDA] <[PDB]

C. [PDA] = [PDB]

A. [PDA] >[PDB]

B. [PDA] <[PDB]

C. [PDA] = [PDB]

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