Terms in this set (9)

Therapeutic Class: Antipyretic and analgesic

Pharmacologic Class: Centrally acting COX inhibitor

Actions and uses: reduces fever by direct action at the level of the hypothalamus and dilation of peripheral blood vessels, which enables sweating and dissipation of heat
-no anti-inflammatory properties; not effective in treating arthritis or pain caused by tissue swelling following injury, primary therapeutic usefulness, treatment of fever, relief of mild to moderate pain, treatment of severe pain, may be combined w opioids
-no effect on platelet aggregation and does not exhibit cardiotoxicity, it does not cause GI bleeding or ulcers

Administration alert: Never administer to patients who consume alcohol regularly due to the potential for drug-induced hepatotoxicity

Adverse effects: generally safe, and adverse effects are uncommon; not recommended in patients who are malnourished, acute toxicity may result, leading to renal failure, signs of acute toxicity include nausea, vomiting, chills, abdominal discomfort, and fatal hepatic necrosis; risk for liver damage

Black box warning: potential to cause severe and even fatal liver injury, cause serious allergic reactions with symptoms of angioedema, difficulty breathing, itching, or rash

Contraindications: chronic alcoholism

Drug-drug: inhibits warfarin metabolism, High-dose or long-term acetaminophen use may result in elevated warfarin levels and bleeding

Lab tests: inc hepatic function test values

Herbal/food: void taking herbs that have the potential for liver toxicity

Treatmen of Overdose: oral or intravenous (IV) administration of N-acetylcysteine (Acetadote) asap, protects the liver from toxic metabolites
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