Terms in this set (15)
Monoclonal antibody to the platelet glycoprotein IIb/IIIa receptor that binds fibrin.
Used to prevention of ischemic complications in patients undergoing percutaneous coronary intervention.
Eptifibatide and Tirofiban act similarly
Reversibly inhibits COX - mostly in CNS. Inactivated peripherally.
Antipyretic, analgesics, but not anti-inflammatory.
Used instead of Aspirin to avoid Reye syndrome in children with viral infection.
Overdose produces hepatic necrosis; acetaminophen metabolite [NAPQI] depletes glutathione and forms toxic tissue byproducts in liver. N-acetylcysteine is antidote - regenerates glutathione.
Acyclovir, Famciclovir, Valacyclovir
Antiviral: Guanosine analogs. Monophosphorylated by HSV/VZV thymidine kinase not phosphorylated in uninfected cells → few adverse effects.
Triphosphate formed by cellular enzymes.
Inhibit viral DNA polymerase by chain termination
HSV and VZV. Weak activity against EBV. No activity against CMV. Used for HSV-induced mucocutaneous and genital lesions as well as for encephalitis. Prophylaxis in immunocompromised patients.
No effect on latent forms of HSV and VZV.
Valacyclovir, a prodrug of acyclovir, has better oral bioavailability.
For herpes zoster, use Famciclovir.
Acyclovir, Famciclovir, Valacyclovir AE
Antiviral: Obstructive crystalline nephropathy and acute kidney injury if not adequately hydrated.
Acyclovir, Famciclovir, Valacyclovir MOR
Antiviral: Mutated viral thymidine kinase
Antiarrhythmic: ↑K+ out of cells → hyperpolarize the cell and ↓ intracellular Ca, decreasing AV node conduction.
DOC for diagnosing/terminating certain forms of SVT.
Very short acting ~ 15 secs
Effects are blunted by Theophylline and Caffeine - Adenosine receptor antagonists
Antiarrhythmic: flushing, hypotension, chest pain, sense of impending doom, bronchospasm
𝛃2-agonist: relaxes bronchial smooth muscle. Short acting.
Used for acute asthma exacerbations.
𝛃2-agonist: Cause tremors & arrhythmia
Bisphosphonate: Pyrophosphate analogs; bind hydroxyapatite in bone, inhibiting osteoclast activity.
Used for Osteoporosis, hypercalcemia, Paget disease of bone, metastatic bone disease, osteogenesis imperfecta.
Ibandronate, Risedronate, Zoledronate
Bisphosphonate: Esophagitis [if taken orally - patients are advised to take with water and remain upright for 30 minutes], osteonecrosis of jaw, atypical femoral stress fractures.
Antigout: Competitive inhibitor of XO → ↓conversion of hypoxanthine and xanthine to urate.
Also used in Lymphoma and Leukemia to prevent tumor lysis - associated urate nephropathy.
Benzodiazepines: Facilitate GABAa action by ↑ frequency of Cl- channel opening.
↓ REM sleep.
Shorter half-life and high addictive potential.