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Endocrine Disorders

Terms in this set (42)

Type 1 & 2
-hyperglycemia > 100 mg% (diabetic state) which is an elevated blood sugar (synthesis and secretion), elevated levels of epinephrine, elevated levels of growth hormone
-glucosuria - glucose renal tubular reabsorption ability *tmax (normal 180 mg%, glucose freely filtered) is exceeded, glucose in urine
-3 Ps - polyphagia (excessive appetite) Polyuria (osmotic diuresis) Polydipsia (excessive thirst)
-Peripheral neuropathy - damage to peripheral nerve microcirculation, decreased or absent DTR, muscle weakness or atrophy
-Hyperesthesia (feet on fire)
-Anesthesia (can't feel feet)
-Elevated blood lipids, atherosclerosis, poor circulation, poor wound healing
-Infections result (Clostridium) Gangrene which could lead to amputations
-Insulin shock - more insulin than needed, severe hypoglycemia develops (<70 mg%) taking insulin without eating breakfast, brain/cns is not getting enough gas, brain runs off glucose, loss of consciousness, shock, followed by death

Type 1
-loss of pancreatic islet cells (autoimmune mechanism**, environment -viruses, chemicals, genetic - several variants)
-need exogenous insulin
-normal body type
-Hyperosmolar Coma (diabetic coma), blood sugar shoots out the roof
-Ketoacidosis - metabolic acidosis result pH <7.35-7.45) Ketone bodies are formed

Type 2
-being overweight
-obesity (decreased sensitivity to insulin, beta cells are fine, decreased number of insulin receptors) (decreased cellular metabolism of glucose, slow down and get lazy)
-oral hypoglycemic agents