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4 terms

Adult T cell Leukemia/Lymphoma

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Adult T cell leukemia/lymphoma
1)Adult t-cell leukemia/lymphoma
2)Mycosis fungoidis
3)Sezary syndrome
Adult T cell leukemia/lymphoma
-what
-virus
-clinical
-micro
What: malignant T-cell disorder(CD-4) due to HTLV-1(human T-cell leukemia virus type 1) infection found in Japan and Caribbean

Clinical
-skin lesions
-hypercalcemia
-enlarged lymph nodes
-heaptosplenomegaly

Micro
-hyperlobated "4-leaf clover" lymphocytes in peripheral blood
Mycosis Fungoidis
-what
-clinical
-micro
What: malignant T-cel disorder CD-4

Clinical:
-benign skin rash that progressis to lymph nodes, lung, liver and spleen

Micro:
-Pautrier microabscesses: aggregates of atypical PAS-positive lymphs in epidermis
Sezary Syndrome
What: mycosis fungoides with a leukemic phase

*basically goes from skin to blood