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classic presentations from first aid for USMLE step 1

No lactation postpartum, absent menstruation, cold intolerance

Sheehan's syndrome (pituitary infarction)

Nystagmus, intention tremor, scanning speech

Charcot's triad 1 (multiple sclerosis)

Oscillating slow/fast breathing

Cheyne-Stokes respirations (central apnea in CHF or ↑ intracranial pressure)

Painful blue fingers/toes, hemolytic anemia

Cold agglutinin disease (autoimmune hemolytic anemia caused by Mycoplasma pneumoniae, infectious mononucleosis)

Painful, pale, cold fingers/toes

Raynaud's syndrome (vasospasm in extremities)

Painful, raised red lesions on palms and soles

Osler's node (infective endocarditis)

Painless jaundice

Cancer of the pancreatic head obstructing bile duct

Palpable purpura, joint pain, abdominal pain (child)

Henoch-Schonlein purpura (IgA vasculitis affecting skin and kidneys)

Pancrealic, pituitary, parathyroid lumors

Wermer's syndrome (MEN 1)

Pink complexion, dyspnea, hyperventilation

Pink puffer (emphysema: centroacinar [smoking], panacinar [α1-antitrypsin deficiency])

Polyostotic fibrous dysplasia, precocious puberty, cafe-au-lait spots, short stature in a young girl

McCune-Albright syndrome (mosaic G-protein signaling mutation)

Polyuria, acidosis, growth failure, electrolyte imbalances

Fanconi's syndrome (proximal tubular reabsorption defect)

Positive anterior "drawer sign"

Anterior cruciate ligament (ACL) injury

Ptosis, miosis, anhidrosis

Horner's syndrome (sympathetic chain lesion)

Pupil accommodates but doesn't read

Argyll Robertson pupil (neurosyphilis)

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