Scheduled maintenance: Saturday, March 6 from 3–4 PM PST
Upgrade to remove ads
Only $2.99/month

HMG-COA Reductase Inhibitors

Terms in this set (18)

Prototype
Atorvastatin (Lipitor)
Common suffix
Statin
Metabolized
Liver
Excreted
Feces, urine
Action
Inhibits HMG-COA enzyme for hepatic synthesis of cholesterol
Use
Hypercholesteremia, reducing CVEs in people with multiple risk factors
Most powerful drug for reduction of
LDL cholesterol
Contraindications
Pregnancy, lactation
Adverse effects
Headache, GI, rhabdomyolysis
Increase effects
Grapefruit juice, pomegranate juice, sitostanol, B3
Goal
Decrease total serum cholesterol, ldl cholesterol, triglycerides, increase hdl cholesterol
Effectivity and max effect
1-2 weeks; 4-6 weeks
Teaching
Birth control for women, monitoring LFT regularly, low fat diet, exercise
Rhabdomyolysis
dissolution of striated muscle
Other statins
Fluvastatin, lovastatin, pravastatin
Statin with highest level of absorption
Fluvastatin
Statins that are poorly absorbed but can be taken with food
Lovastatin, pravastatin
DO NOT DRINK WITH MEDS
grapefruit juice
THIS SET IS OFTEN IN FOLDERS WITH...