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19 terms

endochondral ossification

describe steps in endochondral ossification
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endochondral ossification
bones replaces existing cartilage
unborn child
bones such as humerus and femur are completely made of hyaline cartilage
cartilage model
forms shape of bone--long bone
cartilage model
formed by chondroblasts
cartilage model
perichondrium forms around model
growth of cartilage model
chondroblasts get buried in matrix and develop into chondrocytes
growth of cartilage model
chondrocytes repoduce and continue secreting cartilage
growth of cartilage model
center of model begins to clacify- causes chain reaction to cell death because nutrients can't travel through calcified areas
primary ossification center
ossification starts from the external surface--invades the middle of the bone
primary ossification center
artery penetrates the perichondrium- causes osteogenic cells to differentiate into osteoblasts
primary ossification center
osteoblasts begin to secrete compact bone tissue
primary ossification center
more blood vessels invade the inner portion of calcified cartilage
primary ossification center
stimulate formation of the primary ossification center--bone tissue replaces cartilage
medullary cavity
primary ossification center expands toward the ends of the bone
medullary cavity
osteoclasts break down existing bone in the middle to form the cavity
secondary ossification center
blood vessels invade the ends of the bones
secondary ossification centers
process is the same as primary centers, but no medullary cavity formed
formation of articular cartilage and epiphyseal plate
cartilage on the epiphyseal remains and is the articular cartilage
formation of articular cartilage and epiphseal plate
cartilage between epiphysis and diaphysis remains as the epiphyseal plate (growth plate)