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What the drug does to the body; involves the mechanism of action. Involves effect of drug concentration on body responses.
Patients have widely different responses to drugs, which can be depicted on a frequency distribution curve.
describes how the actions of a drug change with increasing dose. Drug dose correlates to degree of response. Three phases: 1. Lowest (administration) 2. Most desirable range 3. Plateau reached
The ratio between the toxic and therapeutic concentrations of a drug. If the index is low, the difference between the therapeutic and toxic drug concentrations is small, and use of the drug is more hazardous.
Drug receptor interaction
-Binding of drug to receptor is usually reversible
-Turns receptor "on" or "off"
-Each receptor regulates a process and generates a response
-Strength of D-R complex is related to "affinity" = high affinity and the drug will have difficulty coming off the receptor
- Once occupied, reseptor triggers secondary messenger
Median Effective Dose
the dosage of a given drug at which 50% of clients experience a specific therapeutic effect. AKA Average dose or ED 50
Median lethal dose
(LD50)the dosage of a given drug at which 50% of clients experience a lethal effect
A membrane protein that forms a channel or pore completely through the membrane and that is usually permeable to one or to a few water-soluble molecules, especially ions.
method of cellular signaling whereby a hormone diffuses into a cell to activate proteins within the cell to cause a response
The movement of substances into or out of cells without the expenditure of energy or the involvement of transport proteins in the cell membrane. Also called simple diffusion.
Mimic the action of endogenous substances (neurotransmitters); response may be greater than endogenous activity.
Prevents action of endogenous substance; may compete with agonist; useful in blocking excess endogenous activity
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