Cholesterol absorber inhibitor
Excess cholesterol stored
Rate limiting step in cholesterol synthesis
Inhibited by cholesterol
Activated by insulin
Excess cholesterol stored in tendons
Increased HDL production
Enhance hepatic lipid metabolism
Apo C2 deficiency
LDL receptor deficiency
Increased risk of CHD
GDA Omega 3 and 6
3 phosphoglycerate--> ______---> cysteine+_______
oxaloacetate--> _______---> asparagine
a-ketoglutarate---> glutamate---> _______
Muscle protein-> amino acid-> Glutamate-> Alanine
Lack of homogentisic acid oxidase
Excrete homogentisic acid
Phenylalanine--> tyrosine--> hydroxyphenylpyruvate--> homogentisic acid--> Fumarate
1 in 10,000
Increase in phenylalanine
RDA protein male and female
Exact amount of protein needed for synthesis
Age: <18 months
Oedema: absent, severe wasting of body fat
Cause: sever malnutrition
Wrinkled skin, hair loss, thin
Age: 1-5 years
Oedema: Present due to low plasma albumin
Odema hides wasting body
Features: Scaly skin, distended abdomen, hepatomegaly, sparse depigmented hair.
Cannot be synthesised in the body
Complex organic substance
Folate---> THF---> synthesis of purines, thymidine, glycine
Folic Acid (B9)
Main iron storage protein
Fe2+ and Haem
Transports iron between tissues.
Acidification of endosome released Fe3+ stored within ferritin
In iron deficiency ferritin translation ______ while transferrin receptor number ________
Poly unsaturated fatty acid
Susceptible to free radical chain reactions
Oxygen free radicals --> Oxygen and hydrogen peroxide
Selenium containing enzyme
Keeps SH part of amino acids reduced
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