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Rate limiting step in cholesterol synthesis
Inhibited by cholesterol
Activated by insulin
Lack of homogentisic acid oxidase
Excrete homogentisic acid
Phenylalanine--> tyrosine--> hydroxyphenylpyruvate--> homogentisic acid--> Fumarate
Age: <18 months
Oedema: absent, severe wasting of body fat
Cause: sever malnutrition
Wrinkled skin, hair loss, thin
Age: 1-5 years
Oedema: Present due to low plasma albumin
Odema hides wasting body
Features: Scaly skin, distended abdomen, hepatomegaly, sparse depigmented hair.
Transports iron between tissues.
Acidification of endosome released Fe3+ stored within ferritin
In iron deficiency ferritin translation ______ while transferrin receptor number ________
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