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27 terms

CVS Drugs

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Quinidine (Quick)
SVW Classification
Class 1a Na channel blocker
Atrial Muscle
Ventricular Arrythmias
Paroxysmal recurrent atrial fib
Prolong AP
Lignocaine (Lids)
SVW Classification
Class 1b Na blocker
Decrease AP
Ventricle
During and after MI
VTach
PropaFenone (Flecking)
SVW classification
Class 1c Na blocker
No change in AP supress automaticity
WPW, recurrent tachyarrythmias
Atenolol (At)
SVW classification
Class 2 B blocker
SA Node+AV Node
Suppress automaticity (decreased sympathetic drive)
SVT tach
Amiodarone (Amiable)
SVW classification
Class 3 K+ blocker
Prolong refactory period
WPW, VTach, AFib
Verapamil (Varied)
SVW classification
Class 4 Ca2+ channel blocker
Block AV node
SVT Tach
Paroxysmal SVT Tach
Digoxin
Vasal stimulant
INcrease Calcium levels via Na+/Ca channel
Bendroflumethazide, hydrochlorothazide
Antihypertensive- Diuretic
Vasodilator
Inhibit Na+/Cl- pump in DCT
Increases K+ outside
defect: electrolyte disturbance
Losartan
Antihypertesive: AG2
Excesss AG2= thirst and Na retention
Defect: Hyperkalemia, diarrhea
Guanedrel
Ganglion blocker
Compete with NA for uptake 1
Inhibit sympathetic effect
Prazosin
A1 receptor inhibitor
alpha 1- vasoconstrictor via PLC
Defect: headaches
Penacidil minoxidil
K+ channel activator
Increase Ca influx
Defect: water retention, hirtuism
Verapamil, nifedipine, amlodopine
Ca+ channel blocker
Vasodilation: reduce peripheral resistance and filling pressure
Defect: oedema, diziness
Captopril, enalapril
ACE inhibitor
Treat HF
Vasodilator
Involves RAAS
Defect: First dose hypotension, taste difference
a-methyl dopa
Pro drug
Competes with NA and displaces it
Converted to methyl NA
Inhibits renin production
Only when other methods fail
Atorvostatin-Statins
Treat atherosclerosis
HMG-CoA reductase inhibitors
LDL decrease
HDL, VLDL receptor increase
Side Effect: myalgias, rhabdomylagias, malabsorption of lipid soluble vit
Cholestipol- Bile Acid binding Agent
Treat athersclerosis
Increase bile acid binding in gut
Side Effects: Decreased absorbtion of lipid soluble vitamins, increase VLDL
Fibrates
Treat artherosclerosis
Increased VLDL decrease LDL
Increased Beta oxidation in liver
Side effects: rhabdomyalgias, myopathy, gallstones
B blocker
Treat angina
Carvedilol- alpha
Propranolol- beta
atenolol- mixed
Side Effects: Hallucinations, skin reactions, constipation
Nitrates
Treat angina+HF
EDRF produce NO- guanylate cyclase
Vasodilation
Sublingual or injection
Side Effects: flushing, palpitations, headache
Clopidogrel
Antiplatelet
Inhibit ADP platelet activation
Blocking cross linking with fibrin
Inhibit clot formation

Side effect: severe neutropenia
Asprin
NSAID
Acetylsalicilic acid to salysilic acid
Inhibit TXA2 production via COX
Side Effect: Gastric ulcers and bleeding
Ranolozine
Inhibit late Na channels
Prolong QT interval
Side Effect: worsen electrical dysfunction
Digoxin/Digitoxin
Positive Inotropic drug
Treat HF
Cardiac glycoside
Na+/ K+ ATPase inhibitor
Calcium influx via Na+/ Cl- pump
Dobutamine
Sympathomimetic
Treat HF
Act on B receptors
Loop Diuretics
K+ Sparing (spironolactone)
Thiazides
Diuretics
Increase plasma oncotic pressure
Sildenafil
cGMP phosphodiesterase inhibitors
Viagra
Inhibit cGMP to GMP