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Lymphocyte that do not need to recognise a specific antigen before releasing toxin.
Tumour cells still susceptible.
Tumour evasion of the CTL response
Increased expression of TGF-B and PGE2
Endocytosis of antigen
Fas and FasL
Conjugated to radionucleide
Conjugated to toxin
Bind to cancer and activate NK cells
Loss of cell to cell adhesion by E cadherin
Attachment to matrix component- laminin
Degradation of ECM
Motility of tumour cells.
Degradation- proteolytic enzymes break away the ECM
Attachment- involvement of intergrin.
How do cells move within the stroma
Type 16 and 18- cervical cancer
DNA intergrated into host genome and E1 and E2
Inhibit E1 and E2 which usually inhibit E6 and E7
E6 and E7 not stopped-uncontrolled growth.
E6 and E7 bind onto pRb and separate it from the E2F (more cell growth)
Increased oestrogen exposure
Increased age, long space between menaupause, high fat diet
Prolonged oestrogen exposure causes endometrial hyperplasia
Risk: obesity, oestrogen replacement therapy
Opportunity for primary cancer prevention
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