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59 terms

OneLiners - Antimicrobials

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Inhibit DNA gyrase
MOA of quinolones
Block cell wall synthesis by inhibiting peptidoglycan cross-linkage
MOA of penicillin
Vancomycin
Drug used for MRSA
Blocks peptidoglycan synthesis
Vancomycin MOA
Point mutation
Type of resistance found with vancomycin
Rifampin
Meningitis prophylaxis in exposed patients
"Scotch tape technique and mebendazole"
Technique used to diagnose perianal itching, and the drug used to treat it
nephro and ototoxicity
Two toxicities of aminoglycosides
Erythromycin
DOC for Legionnaires' disease
Inhibit dihydropteroate synthase
MOA of sulfonamides
Methicillin, nafcillin, and dicloxacillin
Penicillins active against penicillinase secreting bacteria
Amoxicillin
Cheap wide spectrum antibiotic DOC for otitis media
Cephalosporins
Class of antibiotics that have 10% cross sensitivity with penicillins
Carbenicillin, piperacillin and ticarcillin
PCN active against pseudomonas
"Vancomycin, infusion at a slow rate and antihistamines"
Antibiotic causing red-man syndrome, and prevention
Tetracycline
Drug causes teeth discoloration
Decreases protein synthesis by inhibiting 30S ribosome
MOA of tetracycline
Chloramphenicol
Drug that causes gray baby syndrome and aplastic anemia
Clindamycin
Drug notorious for causing pseudomembranous colitis
Metronidazole
DOC for tx of pseudomembranous colitis
ORAL vancomycin
Treatment of resistant pseudomembranous colitis
Megaloblastic anemia
Anemia caused by trimethoprim
Cartilage damage
Reason fluoroquinolones are contraindicated in children and pregnancy
Metronidazole
DOC for giardia, bacterial vaginosis, pseudomembranous colitis, and trichomonas
Rifampin, Isoniazid, Pyrazinamide, and Ethambutol
Treatment for TB patients (think RIPE)
Disulfiram-like reaction
Metronidazole SE if given with alcohol
Red urine discoloration
Common side effect of Rifampin
Bind ergosterol in fungal cell membrane
MOA of nystatin
Administration of Vit. B6 (pyridoxine)
Neurotoxicity with isoniazid (INH) prevented by
Nephrotoxicity
Toxicity of amphotericin
Gynecomastia
SE seen only in men with administration of ketoconazole
Topical mupirocin (Bactroban)
Topical DOC in impetigo
Amantadine
DOC for influenza A
Ribavirin
DOC for RSV
Ganciclovir
DOC for CMV retinitis
Neutro, leuko and thrombocytopenia
SE for ganciclovir
Nevirapine, amprenavir
Anti-viral agents associated with Stephen Johnson syndrome
Protease inhibitors
HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism
Delavirdine, efavirenz, and ribavirin
Antivirals that are teratogens
Ganciclovir, zidovudine, saquinavir, and interferon
Antivirals associated with neutropenia
AZT (zidovudine)
HIV med used to reduce transmission during birth
Suramin
Drug used for African sleeping sickness
Nifurtimox
Drug used in Chagas disease
Cefuroxime (2nd) generation, Ceftazidime, Ceftriaxone
Cephalosporins able to cross the BBB
Cefixime (3rd) generation
Cephalosporins NOT able to cross the BBB
Ceftriaxone
Drug used for N. gonorrhea in females
Ceftriaxone or cefuroxime
Cephalosporin causes kernicterus in neonates
Peripheral neuritis and hepatitis
SE of INH
Streptomycin
Aminoglycoside that is least ototoxic
Primaquine
Drug used in exoerythrocytic cycle of malaria
Minocycline
Oral antibiotic of choice for moderate inflammatory acne
Dapsone, rifampin and clofazimine combination
Drug of choice for leprosy
Acyclovir; incorporated into viral DNA and chain termination
DOC for herpes and its MOA
Sulfonamides
Anti-microbials that cause hemolysis in G6PD-deficient patients
Inhibition of protein synthesis at the 50s subunit of ribosome
MOA of erythromycin
Sulfamethoxazole/Trimethoprim
Anti-biotic frequently used for chronic UTI prophylaxis
Aztreonam
Lactam that can be used in PCN allergic patients
Seizures
SE of imipenem
Didanosine
Anti-viral with a dose limiting toxicity of pancreatitis