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housed monkeys individually for four and a half years and then placed in social cages of four monkeys each. Research observed the monkeys and found that being low in social dominance is stressful. dopamine levels were low in monkeys of isolation when self-administered cocaine was made available the monkeys of isolation were more likely to get hooked.
Constant drug use leads to periodic dopamine highs, the body releases CRF to maintain a homeostatic state by reducing dopamine. Repetition of this puts too much pressure on the homeostatic system, so the body cues a physiological reaction raising the hedonic set point making it almost impossible for increased dopamine levels to trigger pleasure; this causes the individual to not be able to experience pleasure from normal things so is likely to relapse and take drug.
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