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pharm final

Terms in this set (89)

Give ____________ with cyclophosphamide to bind up ____________ metabolite and prevent ____________
mesna
acrolein
hemorrhagic cystitis
____________ is anti-CTLA4 for cancer
ipilimumab
check ____________ genotyping with azoothioprine
TMPT
____________ is number one for treating organ transplant rejection
mycophenolate metofinil
MTX at low doses
increases adenosine levels too inhibit neutrophils
treat MTX microcytic anemia with
leucovorin
MTX is ____________ eliminated
renally
calcineurin inhibitors
cyclosporine A and tacrolimus
____________ is 10-100X more potent calcineurin inhibitor but watch out for ____________
tacrolimus
glucose intolerance
____________ is an anti-IL6 ab
tocilizumab
____________ is approved for cytokine release syndromoe
tocilizumab
____________ is an IL1 ab
anakinra
____________ is a CTLA4 fusion prootein
abetacept
____________ is an anti-cola ab
ipilimumab
____________ is the most renal toxic NSAID
diclofenac
____________ has a 5 day max NSAID because of high risk of GI hemorrhage
ketorolac
____________ is a typical antipsychotic used for tourettes and delusional parasitosis
pimozide
lithium MOA: depletes intracellular ____________
inositol
SSRI MOA:
increase win BDNF
SSRI 2D6 inhibitors
parocetine
fluoxeting
SSRI cyp3A4 inhibitor
fluvacoxamine
____________ is an SSRI associated with prolonged QT
citalopram
SSRI discontinuation syndrome worst with
paroxetine
SSRI discontinuation syndrome not seen with ____________
fluoxetine
____________ is SNRI that leads too hepatotoxicity
deloxetine
desvenlafaxine is SNRI that leads to ____________
increased BP and HR
TCAs undergo ____________ metabolism
CYP2D6
____________ is a TCA used for insomnia
doxepin
nefazodone taken off the market because of
lethal hepatotoxicity
esketamine MOA and side effect
NMDA antagoniist
dissoociation
____________ used for post party deppression
-allosteric modulation of GABA
brexanalone
treat alcoholism with
naltrexone
acamprosate
disulfiram
opiod intoxication leads to
itch
treat opioid withdrawal with
methadone oro cloniidine
synthetic cannabinoids: ____________ and ____________

used too treat ____________ and ____________
nabilone
dronabinool

anti-emetics
treats cachexia
PCP associated with ____________
vertical nystagmus
____________ associated with intense thirst
MDMA
____________ is a new antiviral for CMS that accommodates a second mutation in UL54
maribavir
____________ is used for prophylaxis off CMV in SCT patients
letermovir
____________ and ____________ are NNRTIs that are CYP inhucers
efavirenz
nevirapine
____________ is a NNRTI that is a CYP inhbitor
delavirdine
____________ is a HIV protease inhibitor
ritanovir
____________ is an HIV protease inhibitor CYP inhibitor that leads to hematuria and nephrolithiasis
indanacir
integrase inhibitors
raltegravir
dolutegravir
elvitegravir
PrEP
tenofovir and emtricitabine
____________ and ____________ are protease inhibitors used i n HepC treatment

they are strong ____________ of CYP3A4
telaprevir
boceprevir
inhibitors
premiavate amphotericin B with ____________ and ____________
diphenhydramine and acetaminophen
side effect of voriconazole: ____________ and ____________
vision and periostitis
does fluconazole penetrate CNS
yes
must take itraconazole with ____________
cocal cola or orange juice
with prosacinazole worry about ____________
adrenal insufficiency
anti fungals are QT ____________ with the exception of ____________
prolonging
isavuconazole
allylamines
terbanafine
tolnaftate
naftifine
don't use caspofungin with ____________
cyclopsporine
clopidogrel is activated by ____________
CYP2C19
in HIT test for ____________
platelet 4 antibodies
____________ is used in HIT patients with hepatic toxicity
lepirudin
____________ is used in HIT patients with renal toxicity
argatiroban
Xa inhibitors are metabolized by ____________
CYP3A4
-dont give with inhibitors
____________ is recombinant factor Xa
andexxa
warfarin is metabolized by ____________
CYP2C9
drugs with high ____________ undergo significant first pass metabolism
hepatic extraction ratio
____________ and ____________ are heavily effected in liver disease

____________ and ____________ are not
CYP3A4 and CYP2C19

CYP2D6 and glucoronidation
CCBS are cyp ____________
inhibitors
codeine undergoes ____________a nd ____________ metabolism
CYP3A4 and CYP2D6
codiene ____________ metabolism converts it to morphine
CYP2D6

ultrametabolismrs get severe tox
____________ is metabolized to active for endoxifin by CYP____________
tamocifen
2D6
CYP 2D9 substrate and inhibitor
warfarin
TMP-SMX
clopidogrel activated by ____________
CYP2C19

inhibited by PPIS
____________ decrease cerebral uptake of levadopa
high protein meals
____________ allele increases risk of myopathy in patient on statins
C
____________ ingestion increases urate
ethanol
with renal insufficiency should you use allopurinol or febuxostat
febuxostat
____________ is a dopamine agonist taken off the market because it caused
pergolide

heart valvular, fibrotic disorders
watch out for ____________ in non-ergot D2 agonists
sleep attacks
____________ is an injectable rescue therapy but has the side effect of ____________
apomorphine
N&V
dont perscribe in parkinson's:
neuroepileptics
antipsychootics
metochlopramide
prochloperazine
____________ is an ergot used for status migranosis
dihydroergotamine
____________ are a new method for chronic migraine treatment without side effects
CGRP inhibitors
____________ is a second generation carbemezapine with less side effects but more hyponatremia
oxcarbenzpine
valproic acid is highly ____________ bound
albumin bound 90%
____________ is a second generation to levetiracetam with less behavioral disturbance
brevaracetam
first line for focal epilepsy: ____________ and ____________
lamotrigeine
oxcarbazepine
first line for generalized seixures
lamotrigine and levitaracetam
first line for status epilepticus
benzos
activated charcoal doesn't work for
alcohols
metals
corrosives
Li
methanol poisoning buzzworf
snowstorm blurred vision
ethylene glycol buzzword
calcium oxalate crystals in urine
iron buzz word
melana
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