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Clinical Micro Exam 3 Q's
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Terms in this set (90)
true or false: lipoteichoic acid is found in both gram-positive and gram-negative organisms.
false
this molecule induces an immune response that activates T-cells and creates a cytokine storm that results in major damage throughout the body
superantigen
intracellular pathogens use special adaptations to survive inside the host cell. an example of a pathogen that survives inside the host is:
salmonella sp
how do microbes acquire resistance?
selection by the environment, being constantly exposed to the antibiotic
true or false: osteomyelitis can develop as a secondary infection
true
infectious dose is an important consideration in disease. E coli O157:H7 can cause disease with a minimum dose of:
1-2 cells
vibrio cholera has a toxin that is:
an AB5 toxin, introduced by a phage
which of these bacteria is likely to be found in the large intestine? (e. coli)
EHEC, EIEC
which list represents the most to least reported cases of bacterial food poisoning?
salmonella, campylobacter jejune, vibrio
classical and El Tor are:
biotypes
The p-pili is a major virulence factor in E. coli causing:
UTI
true or false: purpura are larger than petechiae
true
type 3 secretion systems are:
made of protein only, deliver effectors to host cells
which of the following forms actin pedestals in the large intestine?
EHEC
infection with helicobacter pylori that develops symptoms results in:
a distinctive odor
which of the following has a toxin that mediates actin remodeling
***
true or false: blobbing of OMV can be an important virulence factor
true
which of the following causes pseudo appendicitis?
yersinia enterolitica
which of the following gains entry to a hos via M cells to cause disease?
shigella sonnei
i isolate a hemolysin that can lyse human blood but not sheep blood. i can say it....?
is called the Kangawa hemolysin, could have come from Vibrio parahemolyticus
a normally healthy 4 year old girl has acute abdominal pain and cramps and also shows signs of pale eyelids and cheeks. her mother reports she is having increased frequency of rust colored urine. the signs and symptoms can be explained by:
HUS caused by E. coli
this organism produces a toxin that specifically causes the disruption of tight junctions:
vibrio cholerae
the only "true" species in the genus Salmonella are:
Bongori and Enterica
which of the following has a protein capsule?
yersinia pestis
an A/E lesion requires:
BFP, intimin
true or false: you are more likely to die from vibrio sp. induced food poisoning if you eat seafood after it was chilled below 13 C.
false
a retired group of firefighters is on tour in India and they have an outbreak of watery diarrhea. the hospital reports that they see evidence of a curved rod without a capsule. a possible cause is:
campylobacter jejunii
a patient with recently diagnosed Crohn's disease has his stool screened for bacterial composition. they compare it to his brother that does not have Crohn's disease. we could suspect that the patient with Crohn's could have _______ in the stool?
AIEC
which of the following has the potential to cause a disease that causes severe nerve damage?
C. jejunii
which of the following grows in the cytosol of a host cell?
shigella dysenteriae
which of the following uses actin pains to move from cell-to-cell?
shigella
which of the following has a toxin that targets DNA?
c. jejunii
virulence in yersinia requires genes that are in the chromosome. these genes include:
T3SS
which of the following is most likely to cause fatal septicemia?
vibrio vulnificus
a 12 year old female returns from camping and presents to her pediatrician complaining of fever, cough with sputum tinged with blood, body aches and wheezing. the doctor noted that she does not have excessive swelling in her lymph nodes. samples of her sputum are plated at 37C. colonies that form are white and mucoid. the most likely cause is:
klebsiella pneumoniae
after returning from a trip to indonesia, a man develops painless nodules on the shaft of his penis. these nodules appear to progress to a wound, but the wound is non-suppurative. what is the most likely causative agent?
klebsiella granulomatis
a patient arrives at the hospital with fever and malaise. they reported some loose stool 3 days earlier but no other symptoms. after 48 hours in the hospital the patient develops a UTI. cultures from the patient show the enterobacterial common antigen is present. we can predict that the patient could have:
P. vulgaris, E. clocoae, Providencia sp
which of the following has a toxin that changes cAMP levels?
v. cholerae
a 25-year old man returns from a trip to the beach where he has been eating seafood "straight from the ocean" all week. within 12 hours of leaving the beach he develops vomiting and diarrhea that seems to pass, then he notices development of blister like lesions on his extremities. what is the likely causative agent?
v. vulnificus
which is more likely to have human-to-human spread?
salmonella enterica Typhi
a 5 year old boy has acute abdominal pain and cramps after eating at a charity cookout. he experiences bloody diarrhea with presence of immune cells. the patient is nauseated but not vomiting and passes the stool easily. we suspect that he has been infected with:
EHEC
which of the following has a toxin that targets vacuole formation?
H. pylori
BFP is required in certain E. coli for virulence. in particular, it is used for:
attachment
a patient with severe dehydration and rice water stool reports to the doctor. organisms from the stool are isolated and the causative organism has no capsule. the most likely causative agent is:
any of the O1 cholerae strains
how does shigella gain entry to a host to cause disease?
via Peyer's patch
Vibrio cholerae
is halotolerant, can grow in the absence of salt, produces ZOT
which of the following is a virulence factor that allows E. coli attachment?
BFP, P-pili, CFA
salmonella is more likely transferred to humans from turtles that are
smaller than 4cm
what is the leading cause of reported bacterial food poisoning?
salmonella sp
true or false: acid peptone enriches for Vibrio cholerae
false
true or false: helicobacter pylori has saga and a T3SS required for virulence
false
ETEC
watery diarrhea, no fever
EPEC
watery diarrhea, fever
EHEC
bloody diarrhea, no leukocytes
EIEC
bloody diarrhea, leukocytes
if you isolated the toxin from a patient with ETEC, it would have ________
cAMP remodeling activity
if you isolated the toxin from a patient with EIEC, it would have
hemolysin activity
which form of e coli forms actin pedestals in the small intestine?
EPEC
which form of e coli forms actin pedestals in the large intestine?
EHEC
which forms of e coli are located only in the large intestine?
EHEC, EIEC
which forms of e coli are located only in the small intestine?
ETEC, EPEC
which form of e coli is located in both the small intestine and the large intestine?
EAEC
which of the following grows in the vacuole of a host cell?
salmonella enterica Typhi
helicobacter pylori
is found in the gastric epithelial cells but does not invade
which of the following can cause a condition that mimics appendicitis?
y. enterolitica
true or false: the A-B toxin of Campylobacter coli causes cAMP remodeling
false
a major virulence factor in E. coli causing UTIs is
P-pili
vibrio parahemolyticus has
kangawa hemolysin
in shigella infections,
bacteria move from cell-to-cell via actin tails, toxins very similar to those in patients with EHEC are produced
true or false: helicobacter pylori has the potential to cause MALT tumors
true
vibrio cholerae has a toxin that is
an AB5 toxin, introduced by a phage
the genus salmonella
has only 2 recognized species, enters via M cells, has 2 large pathogenicity islands required for virulence
yersinia pestis capsule is made of
proteins
which of the following has been associated with Crohn's disease?
AIEC
true or false: C. jejunii causes Guillian-Barre syndrome in 3/100 cases
false
true or false: salmonella has two different T3SS used for virulence
true
vibrio vulnificus
is oxidase positive, has 50% mortality when present in the bloodstream, is yellow on TCBS
true or false: H. pylori is protective for people with celiac disease
true
The CDT toxin from C. jejunii targets
DNA
virulence in Yersinia requires genes that are not in the chromosome. these genes include:
a protein called F1
which is more likely to have human-to-human spread?
yersinia pestis - pneumonic plague
a 12 year old female returns from camping in a national park. she presents complaining of rapid onset fever, cough without blood, body aches, and wheezing. she continues to be very weak and the doctor takes a sample of her sputum and plates it at 37C. each colony that forms is white but not mucoid in appearance. the most likely cause is
yersinia pestis - pneumonic plague
after returning from a trip to indonesia a man develops painless nodules on the shaft of his penis. these nodules appear to progress to a wound and the wound is non-suppurative. what is the most likely cause of this?
klebsiella granulomatis
a patient with severe dehydration and rice water stool reports to the doctor. organisms from the stool are isolated and the causative organism has a capsule. the most lily cause of this is
v. cholerae 0139
true or false: EHEC has BPF as a virulence factor
true
true or false: C. fetus is routinely transferred from humans to cats
false
a 5 year old boy with shigella sonnei develops thrombocytopenia. this means we can expect to find
shiga toxin, intracellular bacteria
which organism causes abnormal microvilli elongation?
DAEC
what flavor of ice cream was linked to disease caused by typhoid mary?
peach
true or false: M-protein can deplete parts of host innate immunity
true
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