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Varicella - Chickenpox and Shingles
Terms in this set (16)
What is the mode of transmission for chickenpox?
*touching open pustules
*coughing and sneezing spreads the virus through the air
Where does the varicella virus initially invade cells?
How is the varicella virus believed to travel from the respiratory membrane to the skin?
by invading WBCs, which then carry it through all the lymph nodes and the entire body.
How does varicella cause pustules and itching?
Once the virus reaches the skin, it infects
epithelial cells and causes them to balloon, and form blisters fill with the virus.
Why isn't the virus cleared from the body like RNA viruses?
The DNA virus eventually retires to "hide" in the sensory neurons. It enters them in the sensory receptors of the skin.
How do varicella viruses get from the sensory receptors to the dorsal root ganglion?
They are able to stimulate transport from the receptors all the way up the axon to the soma, where they go latent for many years (or forever).
A reactivation of the chickenpox virus in the body, causing a painful rash.
Why is shingles localized to certain dermatomes?
The virus does not reactivate in every dorsal root ganglion.
Dorsal Root Ganglion (DRG)
associated with the dorsal horns of the spinal cord; cell bodies of sensory neurons are located here
Area of skin supplied by a single spinal nerve
Chickenpox and shingles are caused by the same _____________.
virus - Varicella Zoster
Chickenpox is a _________________________ infection, whereas shingles is confined to certain ___________________________.
The vaccine for shingles is ___________ concentrated than that for chickenpox.
Why is the shingles vaccine more concentrated than that for chickenpox?
It is given to immunosuppressed elderly people that do not have a strong immune response.
Theoretically, the __________________________ your immune response to chickenpox, the _______________________ likely you will have a reactivation of the virus (leading to shingles).
Recommended textbook explanations
Biocalculus: Calculus for the Life Sciences
Campbell Biology (AP Edition)
Cain, Jackson, Minorsky, Reece, Urry, Wasserman
Biocalculus: Calculus, Probability, and Statistics for the Life Sciences
Campbell Biology (AP Edition)
Cain, Campbell, Minorsky, Reece, Urry, Wasserman
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