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TAMHSC Endocrinology

Key Concepts:

Terms in this set (8)

ABC Stuart & Me Gulp Da PP 2 INHIBIT Sex & GLuTtony THen... PRAnce
[Alpha-glucosidase inhibitors (acarbose, miglitol, voglibose) (Mech: --| degradation of complex carbs)(AE: GI effects),
Biguanide (Metformin) (Mech: --| hepatic mtGPD (gluconeogen) & ↑ insulin-mediated glucose uptake in muscle/fat) (AE: GI effects, lactic acidosis, decreased B12 absorption),
Secretagogues (Includes next 4 groups = Sulfonylureas, Meglitinides, GLP-1 Receptor Agonists, DPP-IV inhibitors)
Sulfonylureas (Tolbutamide, Tolazamide, Chlorpropamide, Glipizide, Glyburide, Glimepiride) (Mech: --| K+ channels in B-cells -> ↑ Ca2+ enters the cell -> ↑ insulin release) (AE: takes a while to clear out of system if hypoglycemic; wt gain)
Meglitinides (Repaglinide, Nateglinide) (Mech: --| K+ channels in B-cells -> ↑ Ca2+ enters the cell -> ↑ insulin release) (AE: takes a while to clear out of system if hypoglycemic; wt gain),
GLP-1 Receptor Agonists (GIP, GLP-1, Exenatide (XR), Lixisenatide, Liraglutide, Dulaglutide, Semaglutide) (Mech: --| K+ efflux and ↑ Na+ influx -> ↑ Ca2+ entry into B cell -> ↑ insulin release) (AE: renal insufficiency & gastroparesis, MEN 2A/B contraindicated, GI effects),
DPP-IV inhibitors (Sitagliptin, Saxagliptin, Linagliptin, Alogliptin) (Mech: ↑ endogenous GLP-1) (AE: CKD, heart failure, pancreatitis),
SGLT2 inhibitors (Dapagliflozin, Canagliflozin, Empagliflozin, Ertugliflozin) (Mech: ↑urinary reabsorption of glucose in PCT) (AE: kidney disease),
Thiazolidiones (Rosiglitazone, Pioglitazone) (Mech: binds PPARgamma -> activates insulin responsive genes) (AE: fluid retention, fractures),
Pramlintide (Amylin Agonist) (Mech: delay gastric emptying, blocks glucagon) (AE: Delayed gastric emptying, hypoglycemia in T1DM)]