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15 terms

Hypersensitivity (IV)

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Type IV is known as
Delayed (Cellular) hypersensitivity (DTH)
DTH can be transferred from a sensitized person to a non-sensitized person by:
sensitized T-lymphocytes or
by a factor from extracts of T-lymphocytes called transfer (TF) which turns on a precommited, Ag-sensitive, T-lymphocyte.
Transfer factor
Substance occurring in T-lymphocytes w/ capacity to transfer delayed hypersensitivity (Type IV) to a normal (non-reactive) individual.
(T/F) Type IV has the same mechanism as CMI
True
Cutaneous reactions to poison ivy and oil poison are example of which type of hypersensitivity?
IV
(T/F) delayed hypersensitivty can be transferred by serum.
False

only by T-cells
Mantoux reaction
term refers to the skin test for tuberculosis. the skin reaction which develops in individuals who have been immunized to tuberculin is a DTH response.

» All members of the genus would elicit the same response.

Locally, DTH is not a big problem. Systemically it is.
Which of the following does not cause DTH?

a. peanut
b. soaps
c. metals
d. poison ivy
e. rubber
a. peanut ✓ → Type I
b. soaps
c. metals
d. poison ivy
e. rubber
Migration Inhibition Factor (MIF)
Stops movement of MΦ.
chemokine
a small protein that directs the migration of phagocytes toward an infected cell and signals them to increase productionf of microbe-killing compounds; part of the inflammatory response.
(T/F) TH1 release INF<SUB>γ</SUB> (cytokine) which activates MΦ
True

TH1 cells also release IL3 and GM-CSF → monocyte production in Bone marrow
Cytotoxines
substance with a specific toxic effect on certain cells.

TH1 cells release INF-α and TNF-β which lead to local tissue destruction.
What are some common conditions associated with DTH?
1. organ <i>allograph</i> rejection
2. Parasite clearance
3. some autoimmune phenomena
Which of the following statements are true?

a. In America, M. tuberculosis is pulmonary
b. M. Brovis can be acquired by consuming contaminated milk and vaccine mostly protects agaisnt this.
c. Vaccination is not recommended in America
All true
Which is true about hypersensitvities:

a. mechanism are NOT abnormal
b. problem is with <b>regulation</b>
both statements are true