Terms in this set (36)
Reticulocyte Count (Retic)
indicates ability of bone marrow to produce RBC's when anemic.
Recit count elevated when anemic.
Vitamin B12 deficiency
Gradual onset of symmetrical peripheral neuropathy starting at the feet and/or arms.
-numbness, ataxia, impaired memory, dementia.
Cancer of the beta lymphocytes (B cells). Night sweats, fevers, pain with ingestion of ETOH, generalized pruritus with painless enlarged lymph nodes, anorexia and weight loss. Higher incident in young adults (20-40yo).
Cancer of lymphocytes and killer cells. >65 years old, night sweats, fever and weight loss, gen. lymphadeopathy (painless). Prognosis is poor
a cancer of the plasma cells. fatigue , weakness and bone pain that is usually located in the back or chest. proteinuria with bence-Jones proteins, hypercalcemia, normocytic anemia. more common in older adults
platelet count less than 150,000/ul.
easy bruising (ecchymosis, petechiae), bleeding gums, spon. nosebleeds and hematuria.
ASA, NSAID's, heparin, coumadin, SSRI's steriods.
Coag disorders: . von Willebrand disease, vit D deficiency, scurvy.
Protein in the blood that carries oxygen
% of RBC's in 1 ml of plasma
Mean Corpuscular Volume (MCV)
Mean Corpuscular Hemoglobin Concentration (MCHC)
Total Iron Binding Capacity (TIBC)
a measure of available transferrin that is left unbound.
elevated if there is not enough iron to transport (IDA)
stored form of iron. Produced in the intestines. Stored in body tissue.
spleen, liver, bone marrow.
Red Cell Distribution Width (RDW)
Measure of the variability of the size of RBCs. Only lab on a "iron panel" that will be elevated in IDA and thalassemia
immature RBCs...Q24h they lose their nucleus and mature into RBC.
an increased number of immature erythrocytes in the blood.
>2.5% of total RBC count.
WBC with differential
Neutrophils or segs: 55-70%
bands or stabs: 0-5%
iron deficiency anemia
H/H, MCV, MCHC, ferritin
Anisocytosis (variation on size) and piokilocytosis (variation in shape)
diagnostic test for IDA
Ferritin/serum iron level is decreased.
150-200 mg/dL of elemental iron.
ferrous sulfate 325 mg TID with vit C or orange juice for better absorption for 3-6 months.
SE of iron
- GI upset
- black-colored stool
Interactions with iron
Avoid taking with:
Recheck iron intervention
retic count and CBC approx. 2 weeks after starting supplementation
A genetic disorder in which the bone marrow produces abnormal hemoglobin (defective alpha- or beta-globin chains).
Ethnic groups: Mediterranean, N. Africa, Middle East and S.E. Asia
Diagnostic test for Thalassemia
Gold standard: Hemoglobin electrophoresis
Thalassemia blood smear
Diagnostic test for Pernicious anemia
Antiparietal antibodies are elevated
Diagnostic test for folate deficiency
decreased folate level
increased homocysteine level
Diagnostic test for B-12 deficiency
decreased B-12 level
Anemia of CKD
Due to decreased endogenous EPO production (kidneys aren't working properly)
EPO stimulating agents may be given and are the DOC
Epoetin alfa (Procrit), Darbepoetin alga (Aranesp)
<80fl - Microcytic
80-96fl - Normocytic
>96fl - Macrocytic
destruction of the pluripotent stem cells inside the bone marrow. The result is pancytopenia.
< 32g/dL - Hypochromic
32-36 g/dL Normochromic
>36 g/dL Hyperchromic
macrocytic, megaloblastic anemia
deficiency in vit B-12, which is necessary for the health of the neurons and the brain and for normal DNA production of RBC's.
Red cell distribution width, indicates degree of variation in RBC size (<15% is normal)
an autoimmune disorder caused by the destruction of parietal cells in the fundus (of the stomach) resulting in cessation of intrinsic factor production.
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