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8 terms

Anemias and leukemias

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ALL Acute lymphocytic leukemia
Rapid onset
Affects children
Of acute leukemias, the most responsive to tx
AML Acute myelogenous Leukemia
Rapid onset
Mostly adults
Worst response to tx of all
CLL Chronic lymphocytic leukemia
Slow progression
>60 ys
M>F
Abnormally small lymphocytes
Lymphoid tissue in blood
Bone marrow
CML Chronic myelogenous leukemia
Slow progression
Middle-aged adults. Rare in children
Philadelphia chromosome
Caused by carcinogenic chemicals and radiation
+Granulocytic precursors (myeloblasts and promyelocytes)
Autoimmune Hemolytic anemia
IgG antibodies combine w/ RBC surface antigens
Antibody coated RBC are sequestered in the spleen (where hemolysis occurs)
Erythroblasosis fetalis
Mother's antibodies attack fetal RBCs when different Rh factor
Sickle cell anemia
African americans
Inherited autosomal recessive
Abnormal type of hemoglobin Hb-S
Valine substituted for glutamic acid in the sixth position
Pernicious anemia
Autoimmune disorder
Lack of intrinsic factor
B12, necessary for RBC formation, is not absorbed in the GI tract because of the lack of IF
Macrocytic anemia
Stomatitis and glositis