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Tophat test 3

Terms in this set (28)

The response initiated by protein kinase A is terminated by ...
dephosphorylation of phosphoproteins by protein phosphatase 1.
Many cancers arise as the result of a breakdown in signaling pathways that control cell proliferation.
true
SH2 domains are ...
protein domains that bind phosphotyrosine-containing peptides.
Which of the following is not a commonly observed consequence of the binding of a signaling molecule to its cell surface receptor?
Increased synthesis of the receptor
CREB is activated by ...
phosphorylation by protein kinase A in the nucleus.
A mutation that causes a G-protein to lose its ability to hydrolyze bound GTP would be expected to have constitutively ...
active alpha subunits
Dynein and kinesin are similar in that they consist of heavy chains with globular heads which bind both .... and ....
ATP; microtubules
When a striated muscle is stimulated to contract, calcium is released primarily from the ...
sarcoplasmic reticulum
The major cation responsible for regulating actin-myosin contraction is ...
calcium
Whether a microtubule shrinks or grows is determined by ...
the rate of GTP-bound tubulin addition relative to the rate of tubulin GTP hydrolysis.
A centrosome is ..
the major microtubule-organizing center in animal cells.
Which of the following is not one of the functions of the cytoskeleton?
Protein translocation into the ER.
Which of the following is not a function of actin-binding proteins?
Incorporation of microfilaments into the extracellular matrix
Tim and Tom are ...
protein translocators in mitochondrial membranes
Most mitochondrial genomes consist of ...
several circular DNA molecules
The outer mitochondrial membrane contains proteins that ...
direct translocation
The citric acid cycle consists of the oxidation of __ __ __ to produce __ __ __.
acetyl CoA; CO2, NADH, and FADH2
What are the two families of small GTP-binding proteins that are involved in the formation of coated vesicles?
Rab and ARF proteins.
A KDEL sequence is necessary for ...
the transport of resident ER proteins from the Golgi to the ER.
Which of the following is not a destination for vesicles leaving the Golgi apparatus?
Mitochondria
The unfolded protein response involves ...
increased synthesis of chaperones.
Polypeptides in the ER are usually larger than polypeptides synthesized from the same mRNA that have not entered the ER.
false
In cell fractionation experiments in which subcellular organelles are separated on the basis of their density, the smooth endoplasmic reticulum is ___ the rough endoplasmic reticulum.
lighter than
In the "pulse-chase" experiment, Palade and colleagues studied the pathway taken by newly secreted proteins in pancreatic acinar cells by labeling them with radioactive amino acids and then determining their progressive location within the cells. Which of the following represents the correct order in which the proteins were identified?
Rough ER -> Golgi apparatus -> secretory vesicles
Ribosomal proteins are synthesized in the nucleolus and then assembled onto rRNAs.
false
The nucleolus is the site where ...
ribosomal RNA is transcribed and ribosomes are partially assembled.
The nuclear lamina associates with ...
both the inner nuclear envelope membrane and chromatin.
All molecules that are in the nucleus are transported by a process that requires GTP.
false
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