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Terms in this set (48)

1.Anti-inflammatory - widely administered in sports for musculoskeletal injuries, chronic joint pain due to inflammation
2.Immune suppression - glucocorticoids are potent immune suppressors (target and reduce activity of lymphocytes [a type of white blood cell]) - administered to treat autoimmune disorders (e.g., lupus, rheumatoid arthritis, Crohn's disease, allergies), organ transplants, etc.
3.Physiological replacement - exogenous glucocorticoids are administered if the body is not producing these compounds naturally - e.g., Addison's disease
Long term effect
-Hyperglycemia (over a long period this can cause insulin resistance: Type II diabetes)
-Insomnia (oral glucocorticoids come with specific instructions for patients - do not take in the evening)
-Stomach ulcers
-Facial swelling (with fat deposition in the face = "moon face")
-Adrenal gland suppression (exogenous cortisone causes negative feedback on endogenous glucocorticoid production)
-Hypertension (via ↑vasoconstriction, ↑cardiac output)
-Obesity (↑ % body fat, ↑lipogenesis, ↑visceral / subcutaneous fat) - glucocorticoids stimulate appetite
Short-term glucocorticoid use moderately increases vigor and reduces feelings of fatigue (feel "jacked") - potential for abuse in endurance athletes
Increases time to exhaustion but decreases VO2max
So at submaximal levels of exercise, may be ergogenic?
Long term: increases glucose concentrations but it comes from skeletal muscle. Leads to diabetes, decrease muscle mass, increase body fat because it gives you this "jacked feeling", osteoporosis
WADA allows to treat things outside competition but not during