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drug -drug interactions, adr's (heme/onc)
Terms in this set (14)
CYP3A4/5 inducer and inhibitor along with p-glycoprotein substrate and inhibitor?
amiloride can cause an increased risk of what with concurrent use of tacrolimus?
aminoglycosides, amphotericin, cisplatin, and ganciclovir can cause and increased risk of what with concurrent use of tacrolimus?
ziprasidone is contraindicated with tacrolimus because it may cause an increased risk of what?
fluoroquinolones should be avoided with concurrent use of which medication as it can cause an increased risk of tendon rupture?
2 common adr's with dexmethasone include?
hypertension and GI upset
rare but serious adr's of tacrolimus include?
cardiomegly, arrythmia, SJS, increased risk of cancer, pancreatitis, acute renal failure
methotrexate is excreted by ?
eltrombopag inhibits the OATP1B1 which would do what to methotrextae and therefore sould be avoided for concurrent use?
decrease clearance and increase toxicity
which drugs will compete with methotrexate for renal tubular secretion therefore increasing toxicity?
aspirin, loops, NSAIDs, penicillins, PPI's, salicylates, and bactrim
what are some rare but serious ADR's of methotrexate?anast
acute renal failure, liver failure, interstitial lung disease, SJS, secondary malignancies, opportunistic infections
anastrazole common ADR's mimic that of what natural phase in a females life?
anastrazole should be avoided with concurrent use of what drug?
tamoxifen will ________ the levels of anastrazole
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