Like this study set? Create a free account to save it.

Sign up for an account

Already have a Quizlet account? .

Create an account


Selective CNS depressants that bind to the BZ binding site on the GABAa receptor on the alpha subunit

GABA binding site

Beta subunit of GABA gated receptors is where this binds

alpha-1 subunit functions

anticonvulsive and and sedative-hypnotic actions

alpha-2 subunit functions

anxiolytic actions

alpha-5 subunit functions

memory impairment

Diazepam binds to these subunits

BZ that binds to a1,2,3, and 5

Zolpidem binds to these subunits

Binds more selectively to alpha-1 subunit


these are inverse agonists at the BZ receptor that negatively modulate GABA function and oppose BZ action


BZ antagonist used to reverse BZ actions.

Short half life


Melatonin receptor agonist with hypnotic actions and lower abuse liablity.

Used for delayed sleep phase syndrome

Actions mediated by MT1 andMT2 receptors in the suprachiasmatic nucleus where the circadian pacemaker is located

CYP1A2 oxidation
-fluvoxamine (antidepressant) increase half life 190fold
-rifampin decrease serum levals via CYP1A2 activation

Affect hormone levels and is contraindicated in pubescent/ prepubescent patients and pregnancy


5ht partial agonist structurally unrelated to BZs used for general anxiety disorder due to gradual onset.

No anticonvulsant or hypnotic actions and minimal sedation or psychomotor impairment

Takes 1-3 weeks to take action and is rapidly absoprbed and undergoes extensive first pass metabolism

Can cause pupillary constriction, anti-cholinergic symptoms, and hypertension(when used with MAOI)

5 functions of Benzodiazepines

2. Hypnotic- idiopathic or behavioral (not in sleep apnea)
3. Anticonvulsant- status epilepticus, absence seizures
4. Preanesthetic
5. Muscle relaxant- suppreses reticular system (doesn't work at nmj)

Sedative and anticonvulsant actions*

Tolerance develops most for these two actions of BZs (*more slowly, clonazepam resistant)

Difference from Non-selective CNS depressants

BZ structure determines their actions at the GABAa receptor
(as opposed to lipophillic nature

Biotransformed in the liver via oxidation or conjugation

Benzodiazepines metabolism

Please allow access to your computer’s microphone to use Voice Recording.

Having trouble? Click here for help.

We can’t access your microphone!

Click the icon above to update your browser permissions and try again


Reload the page to try again!


Press Cmd-0 to reset your zoom

Press Ctrl-0 to reset your zoom

It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.

Please upgrade Flash or install Chrome
to use Voice Recording.

For more help, see our troubleshooting page.

Your microphone is muted

For help fixing this issue, see this FAQ.

Star this term

You can study starred terms together

Voice Recording