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Psychopharmacology final shsu
Terms in this set (24)
Profound alterations of mood
Persistent Depressive Disorder (Dysthymia)
condition involving chronic depressive symptoms that are present most of the day for more days than not during a 2-year period with no more than 2 months symptom-free
Is depression a chemical imbalance?
No, it is a deficiency of neurotransmitters
2nd messenger system
CREB- cAMP response - element binding protein
Brain-derived neurotrophic factor (BDNF)
a protein in the nervous system that promotes survival, growth, and the formation of new synapses
2nd messenger system functions
1. Protect neurons from trauma
2. Health and stability of new neurons
Neurogenic Theory of Depression
Depression causes physical changes/damage to brain tissue
Existing neurons can repair and remodel themselves
The brain is capable of making new neurons
Where are new neurons formed?
creation of new neurons in the adult brain
What is the most significant cause of depression?
an umbrella term for disorders in which there is a progressive loss of the structure or functions of the neurons
chemicals that enhance the development and survival of neurons
Proteins that encourage the growth, development, and survival of neurons. They are also involved in neuronal signaling.
Tricyclic antidepressant prototype: blocks reuptake of norepinephrine and serotonin. Tox: ANS (alpha and muscarinic) blockade, cardiac arrhythmias
monoamine oxidase inhibitor
First generation antidepressant
Why are TCAs considered "dual action"?
They block presynaptic reuptake for both norepinephrine and serotonin
TCAs side effects
anticholingeric - dry mouth, blurred vision, constipation, memory problems
antiadrengeric - orthostatic hypotension
antihistaminergic - sedation and wgt gain
ekg changes, cardiac dysrhythmias
known to induce hypomania
blocking acetylcholine receptors causes
Memory and cognitive impairments
Therapeutic drug monitoring
The process of measuring drug levels to identify a patient's drug exposure and to allow adjustment of dosages with the goals of maximizing therapeutic effects and minimizing toxicity.
TCAs are metabolized by
Inhibits transmission of parasympathetic nerve impulses
Anticholinergic side effects
-Tachycardia: abnormally rapid heart rate
-Impotence: lack of erectile penis function.
-GI dysfunction: decreases
-Cyclopegia: paralysis of lens in eye to remain flat
Do TCAs cross placental barriers?
They do not seem to effect language development or behavioral development in utero
No fetal abnormalities associated
TCAs clinical limitations
Wide variety of effects on CNS
Can cause cardia arrhythmias
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