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Intestinal stem cells

Terms in this set (40)

Where are the stem cells in the intestinal epithelium?
Base of the crypt
Movement of cells in the intestinal epithelial layer?
Transient amplifying cells located above Paneth cell crypt area continuously divide and progeny cells migrate upwards towards top of villi
Goblets cells?
Secrete mucus
Paneth cells?
Secrete bacterial products (like lysozyme and defensins)
enteroendocrine cells
Secrete hormones
Enterocytes
specialized absorptive cells in the villi of the small intestine
Tuft cells
Sense lumenal contents
M cells
Cells involved in mucosal immunity
Name of the intestinal stem cells?
+4 and CBC/LGR5 stem cells
Characteristics of +4 intestinal stem cells?
Retain labels (therefore probably quiescent) and resistant to damage
Characteristics of CBC/LGR5 intestinal stem cells
Proliferative and damage sensitive
Hierarchy of small intestinal stem cells?
Lgr5+ cells -> Absorptive progenitor -> enterocyte
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V
Non-cycling precursor cell (+4 LRC) -> Cycling secretory progenitor -> Goblet or paneth or enteroendocrine cell
Which cells in the small intestine have their own progenitor cell?
Enterocytes
Which stem cells are in charge of natural tissue turnover vs injury?
Lgr5+ cells replace cells from natural tissue turnover
+4 stem cells respond to injury check on panopto
What two reasons do +4 stem cells dedifferentiate into Lgr5+ stem cells after injury?
To produce more enterocytes as well as other cells and to replace them as they are more sensitive to damage
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