1. The person's psychosocial processes, meaning his or her thoughts, emotions, and spoken words, interact with the social and cultural environments. These informational interchanges, for example, information concerning the nature of the disease and its cure, can
affect its outcome.
2. The pathogen not only affects the person's physiology, but the actions of the person's immune system also alter the pathogen. This two-way
interaction represents an exchange of information between host and pathogen, if we consider that each is learning something from the other.
3. The treatment still acts to alter the disease state, as it did in the first example. However, the model includes interactions among the treatment, pathogen, and host, and the social environment and psychosocial functioning as processes that affect treatment outcome.