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Patho-FinalReview(Adrenal Dz's)
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Terms in this set (25)
Pseudohypoparathyroidism
↓ Ca2+ w/ normal to ↑ PTH
end-organ resistance to PTH
Knuckle knuckle dimple dimple
Pseudohypoparathyroidism
The most common cause of hypercortisolism is ?
Exogenous /Iatrogenic
Most common cause of
1ry hyperaldosteronism
is ?
Bilateral idiopathic hyperaldosteronism
The most common cause of
endogenous
ACTH-
independent
hypercortisolism is ?
Adrenocortical adenoma
The most common cause of
2ry
HTN is ?
1ry
hyperaldosteronism
The most common enzymatic defect in CAH is?
21-hydroxylase deficiency
_____of
21-hydroxylase deficiency
cases are accompanied by
aldosterone
deficiency.
1/3rd
Virilization in females ?
1-Hirsutism
2-
Acne
in
post
pupertal girls
3-Pseudohermaphroditism in infants
4-
Clitoral
hypertrophy
5-Oligomenorrhea
Ambiguous genitalia
condition in which an infant's external genitals don't appear to be clearly either male or female
The most common cause of
chronic
adrenal insufficiency in
developed countries
is ?
Autoimmune
adrenalitis
The most common adrenal
malignancy
is?
Metastases esp from
lung
&
breast
The most common tumor of
adrenal medulla
in
adults
is ?
Pheochromocytoma
Extraadrenal
pheochromocytoma ?
Paragangliomas
Serious complications that may occur in
pheochromocytoma
include?
1-Catecholamine
cardiomyopathy
2-Catecholamine-induced
myocardial instability
3-
Ventricular arrhythmias
4-CVAs
Zellballen pattern is a key feature of ?
pheochromocytoma
The most common
extracranial solid
tumor of
childhood
is ?
Neuroblastoma
The most common site for
neuroblastoma
is ?
Abdomen (particularly
adrenal medulla
)
Homer-Wright rosettes
Neuroblastoma
which stage of neuroblastoma are relatively associated w/
excellent
prognosis w/
minimal therapy
?
4S
Most children have neuroblastoma are presented w/ stage ?
3 or 4
Age-group of neuroblastoma stage
4S
?
infants younger than 1 yr
"Unresectable unilateral tumor infiltrating across
the midline
w/ or w/o
regional
LN involvement ",which stage of neuroblastoma is best described by the previous definition?
stage
3
"Localized unilateral tumor w/
contralateral
regional LN involvement",which stage of neuroblastoma the previous description suits ?
Stage
3
NF1 protein:
-classified as ?
-regulates?
GTPase-activating protein
RAS activity
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