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Patho-FinalReview(Adrenal Dz's)

Terms in this set (25)

Pseudohypoparathyroidism
↓ Ca2+ w/ normal to ↑ PTH
end-organ resistance to PTH
Knuckle knuckle dimple dimple
Pseudohypoparathyroidism
The most common cause of hypercortisolism is ?
Exogenous /Iatrogenic
Most common cause of 1ry hyperaldosteronism is ?
Bilateral idiopathic hyperaldosteronism
The most common cause of endogenous ACTH-independent hypercortisolism is ?
Adrenocortical adenoma
The most common cause of 2ry HTN is ?
1ry hyperaldosteronism
The most common enzymatic defect in CAH is?
21-hydroxylase deficiency
_____of 21-hydroxylase deficiency cases are accompanied by aldosterone deficiency.
1/3rd
Virilization in females ?
1-Hirsutism
2-Acne in postpupertal girls
3-Pseudohermaphroditism in infants
4-Clitoral hypertrophy
5-Oligomenorrhea
Ambiguous genitalia
condition in which an infant's external genitals don't appear to be clearly either male or female
The most common cause of chronic adrenal insufficiency in developed countries is ?
Autoimmune adrenalitis
The most common adrenal malignancy is?
Metastases esp from lung & breast
The most common tumor of adrenal medulla in adults is ?
Pheochromocytoma
Extraadrenal pheochromocytoma ?
Paragangliomas
Serious complications that may occur in pheochromocytoma include?
1-Catecholamine cardiomyopathy
2-Catecholamine-induced myocardial instability
3-Ventricular arrhythmias
4-CVAs
Zellballen pattern is a key feature of ?
pheochromocytoma
The most common extracranial solid tumor of childhood is ?
Neuroblastoma
The most common site for neuroblastoma is ?
Abdomen (particularly adrenal medulla)
Homer-Wright rosettes
Neuroblastoma
which stage of neuroblastoma are relatively associated w/ excellent prognosis w/ minimal therapy ?
4S
Most children have neuroblastoma are presented w/ stage ?
3 or 4
Age-group of neuroblastoma stage 4S ?
infants younger than 1 yr
"Unresectable unilateral tumor infiltrating across the midline w/ or w/o regional LN involvement ",which stage of neuroblastoma is best described by the previous definition?
stage 3
"Localized unilateral tumor w/ contralateral regional LN involvement",which stage of neuroblastoma the previous description suits ?
Stage 3
NF1 protein:
-classified as ?
-regulates?
GTPase-activating protein
RAS activity
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