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36 terms

MEDCHEM test 1

Enzyme pairing
STUDY
PLAY
The Amplichip DNA microarray is used to genotype
CYP2D6/CYP2C19
phenotypes include measuring thermal stability and/or enzyme activity in RBCs for
COMT
enzyme that catalyzes the addition of methyl groups to drugs
COMT/TPMT
TATA box polymorphisms (TA repeats) are common for
UGT1A1
The Invader Molecular Assay is used to detect mutations in
UGT1A1
Codeine-Morphine ratios can fluctuate in patients with polymorphisms in
CYP2D6
Strattera (atomoxetine) pharmacogenetics involve
CYP2D6
Dopamine levels can be altered with polymorphisms in
COMT
Enzyme genotypes of this enzyme include insertions (I) and deletions (D)
ACE
Catalyzes the addition of glucoronic acid to drugs
UGT1A1
Polymorphisms in this enzyme(s) represents a pharmacodynamic issue
ACE/VKORC1
Which is the next enzyme responsible for the majority of Phase I drug metabolisms other than CYP3A4?
CYP2D6
Important enzyme implicated in coagulation cascade
VKORC1
Implicated in detoxifying drugs used to treat Acute Lymphoblastic Leukemia
TPMT
SN-38 metabolism is affected by polymorphisms in
UGT1A1
Enzyme that converts ironotecan to SN-38
Esterase
Enzyme responsible for the largest percent of drug metabolisms
CYP3A4
(S)-Warfarin is metabolized by this polymorphic enzyme
CYP2C9
Enzyme that detoxifies thiopurines through methylation
TPMT
Polymorphisms include insertion and deletion of alleles
ACE
Phase II enzyme that metabolizes SN-38
UGT1A1
Polymorphic enzyme that metabolizes isoniazid, hydrolazine, and procainamide by acetylation
NAT-2
Grapefruit juice inhibits this enzyme
CYP3A4
This enzyme is involved in the initial conversion of the antiplatelet agent prasugel (Effient) to an inactive metabolite
Esterase
Paragon Dx rapid genotyping assay genotypes these two enzymes in order to adjust warfarin dose
CYP2C9/VKORC1
Phenytoin is metabolized by these two enzymes
CYP2C9/CYP2C19
One of the first examples selected by the FDA for inclusion of pharmacogenetic information in drug labeling
TPMT
Metronidazole is an inhibitor of
CYP2C9
Co-administration of codeine (CYP3A4 and CYP2D6) with the CYP3A4 inhibitor clarithromycin can lead to life-threatening respiratory depression in individuals who are
CYP2D6 ultrarapid metabolizers
The variability in warfarin dosing can be explained by polymorphisms in
CYP2C9/VKORC1
Bilirubin's clearance is largely due to
UGT1A1
Omeprazole is metabolized by
CYP2C19
Verigene is a test for genotyping these enzymes
CYP2C9/VKORC1
Infinity is a test for genotyping these enzymes
CYP2C9/VKORC1
eSensor is a test for genotyping these enzymes
CYP2C9/VKORC1
Invader is a test for genotyping
UGT1A1