The Amplichip DNA microarray is used to genotype
phenotypes include measuring thermal stability and/or enzyme activity in RBCs for
enzyme that catalyzes the addition of methyl groups to drugs
TATA box polymorphisms (TA repeats) are common for
The Invader Molecular Assay is used to detect mutations in
Codeine-Morphine ratios can fluctuate in patients with polymorphisms in
Strattera (atomoxetine) pharmacogenetics involve
Dopamine levels can be altered with polymorphisms in
Enzyme genotypes of this enzyme include insertions (I) and deletions (D)
Catalyzes the addition of glucoronic acid to drugs
Polymorphisms in this enzyme(s) represents a pharmacodynamic issue
Which is the next enzyme responsible for the majority of Phase I drug metabolisms other than CYP3A4?
Important enzyme implicated in coagulation cascade
Implicated in detoxifying drugs used to treat Acute Lymphoblastic Leukemia
SN-38 metabolism is affected by polymorphisms in
Enzyme that converts ironotecan to SN-38
Enzyme responsible for the largest percent of drug metabolisms
(S)-Warfarin is metabolized by this polymorphic enzyme
Enzyme that detoxifies thiopurines through methylation
Polymorphisms include insertion and deletion of alleles
Phase II enzyme that metabolizes SN-38
Polymorphic enzyme that metabolizes isoniazid, hydrolazine, and procainamide by acetylation
Grapefruit juice inhibits this enzyme
This enzyme is involved in the initial conversion of the antiplatelet agent prasugel (Effient) to an inactive metabolite
Paragon Dx rapid genotyping assay genotypes these two enzymes in order to adjust warfarin dose
Phenytoin is metabolized by these two enzymes
One of the first examples selected by the FDA for inclusion of pharmacogenetic information in drug labeling
Metronidazole is an inhibitor of
Co-administration of codeine (CYP3A4 and CYP2D6) with the CYP3A4 inhibitor clarithromycin can lead to life-threatening respiratory depression in individuals who are
CYP2D6 ultrarapid metabolizers
The variability in warfarin dosing can be explained by polymorphisms in
Bilirubin's clearance is largely due to
Omeprazole is metabolized by
Verigene is a test for genotyping these enzymes
Infinity is a test for genotyping these enzymes
eSensor is a test for genotyping these enzymes
Invader is a test for genotyping
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