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69 terms

Immunology Midterm

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CD40 (2) ligand
CD40L (CD154)
B7 (CD80/86)
CD28
Name 4 receptor/ligand pairs found between a cytotoxic T cell and a target cell.
CD2 -- LFA-3

LFA-1 -- ICAM-1

CD45 -- CD22

TCR/CD8 -- MHC Class I + foreign peptide
Name 2 components of the pre-BCR.
V segment + u constant chain (heavy chain)

sai pseudo-light chain
Name 2 components of the BCR
V segment + u constant chain (heavy chain)

kappa or lambda light chain
What is the pan B cell marker?
CD19
Phagosome
formed from endocytosis of a microbe
CD14 aka
LPS receptor
What amino acid is found in high amounts in defensins?
cysteine
To what region do superantigens bind to?
V beta region of TCR
What enzyme is involved in activation/inhibition of NK cells upon binding to a normal/target cell?
tyrosine kinase
What domain of the MHC class 1 antigen interacts with a CD8+ Tc cell?
alpha-3
Which chromosome encodes MHC in mice?
chromosome 17
What 2 chains make up the peptide binding cleft of MHC 1 and MHC 2 molecules?
MHC 1: alpha-1, alpha-2

MHC 2: alpha-1, beta-1
Name the 3 professional APCs.
dendritic cells

B cells

macrophages
Immunological synapse
interface between APC and T cells
Junctional diversity concludes the process of somatic recombination or V(D)J recombination, during which the different variable gene segments (those segments involved in antigen recognition) of TCRs and immunoglobulins are rearranged and unused segments removed. This introduces double-strand breaks between the required segments. These ends form hairpin loops and must be joined together to form a single strand. This joining is a very inaccurate process which results in the variable addition or subtraction of nucleotides and thus generates junctional diversity.
Which selectin is expressed on endothelium following exposure to IL-1 and TNF?
E-selectin
What is the most efficient antigen presenting cell?
dendritic cell
Name 2 chemotactic molecules for neutrophils.
IL-8 (CXCL8)

C5a
Which Th cells are associated with intracellular infections?
Th1 cells
Which selectin molecule is translocated from the endothelial cell cytoplasm to the cell surface upon exposure to histamine?
P-Selectin
Which blood cells have Fc-epsilon-receptors?
eosinophils
Which selectins are expressed on circulating lymphocytes in non-inflammatory states.
L-selectin
CD21 is aka
CR2
Th3 cells are aka
Tr2 cells
Are neutrophils APCs?
NO!
What region of an Ig determines its idiotype?
variable region
Allotype
small amino acid differences in the Ig constant regions
What chain and region of an Ig determines its isotype?
heavy chain constant region
How many molecules are yielded from papain digestion of Ig?
3
What are the 1st leukocytes to arrive at a site of infection?
neutrophils
Which 2 antibodies can activate the classical pathway of complement?
IgG

IgM
CR2 binds which virus?
Epstein-Barr virus
Name the 3 CDs that make up the B cell co-receptor complex.
CD19

CD21

CD81
During what stage does initial transcription of the kappa or lambda light chain occur?
immature B cell stage
During what stage does somatic recombination of the BCR light chain occur?
pre-B cell stage
What are Bence Jones proteins?
light chain Ig in urine
Which cytokine requires a second signal in order to up regulate iNOS?
TNF
Name 2 sources of hypochlorite in innate immunity.
NADPH oxidase

lysosomal granules
Which Ig can activate the alternative pathway of complement in its aggregated form?
IgA
Which Ig is expressed on immature B cells?
IgM
Which of the following is NOT an anaphylatoxin: C2a, C3a, C4a, C5a
C2a
Name a receptor for C3bi
CR2
During which B cell stage is CD19 first expressed?
pro-B cell stage
During which B cell stage is CD20 first expressed?
pre-B cell stage
Mutation of what protein causes X-linked Agammaglobulinemia (Bruton's)?
Btk kinase
What is combinatorial association?
somatic recombination
Which Ig has 2 subtypes?
IgA
Which Ig is the best agglutinator of RBCs?
IgM
What is the "pan marker" for T cells? Hint: it is the 1st molecule to be expressed.
CD2
Which activated T cell ligand is required for optimal activation of B cells?
CD40L (CD154)
Nam 2 CDs that make up VLA-4.
CD49d

CD29
IL-4 cells (3)
mast cells

Th0

Th2
IL-23 cells (2)
macrophages

dendritic cells
TNF cells (2)
macrophages

Th1
Where is GLYCAM1 found?
HEVs of lymph nodes
GM-CSF cells (2)
macrophages

T cells
IL-15 shares many biological properties with which cytokine?
IL-2
IL-15 cells (3)
nonlymphoid tissues (epithelial, fibroblasts)

monocytes/macrophages

dendritic cells
What 3 cells have CR1?
erythrocytes

B cells

phagocytes
Which complement fragment is a chemoattractant for neutrophils?
C5a
IL-18 cells (2)
monocytes/macrophages

dendritic cells

*non-immune cells as well
What domain found on NALP3 is the recognition portion for various ligands?
leucine-rich domain (LRR)
What 3 cells express CD200?
B cells

T cells

dendritic cells
Name an integrin expressed on monocytes but not on neutrophils.
VLA-4 (CD49d & CD29)
What 2 CDs make up MAC-1?
CD11b

CD18
What 2 types of cells have MAC-1 integrin?
monocytes

neutrophils
Name 3 blood cells that have VLA-4 (CD49d & CD29) integrin.
lymphocytes

monocytes

eosinophils