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GI module 3 part 2: tiwari
Terms in this set (31)
inflammation of the liver
how do you determine etiology of hepatitis?
Type A hepatitis
replicates in GI tract and feces and is seen in outbreaks with children
comes from not washing hands, daycares
Type B hepatitis
serum, saliva, and semen
-released in bodily fluids
there is a vaccine for hepB
Type C hepatitis
associated with blood transfusions and is major cause of hepatitis C
Type D hepatitis
comes from contaminated needles
similar to type A as it comes from fecal-oral routes and is water-born
-unique because if pregnant females it will cause high mortality
What are the phases of the prodrome phase?
what is the pre-icteric phase?
fever, fatigue, anorexia, abdominal pain
GI symptoms: nausea, vomiting
what is the icteric phase?
continued signs and symptoms of pre-icteric phase
-dark colored urine-->bilirubin present
-clay colored stool--->bilirubin is absent
-Jaundice--> yellow skin and yellow sclera from bilirubin
Which hepatitis are vaccine preventable?
Hep A and B
how are the vaccines administered for adults?
intramuscularly (deltoid muscle) for adults
how are the vaccines administered for infants?
intramuscularly into the anterior surface of the thigh
If a person is immune to hep type B, what other hepatitis are they immune to?
Hep type D
Hep A vaccine
Hep A and Hep B vaccine
Why does HIV drugs work on Hep B virus?
they both share reverse transcriptase enzyme
What is the etiologic age of HepB?
it has a partial dsDNA and a dane particle
-it is part of the hepadnaviridae
Describe the treatment for HepB virus?
-given a compound called PEGylated interferon that blocks virus and will be absorbed more slowly because it has a strong half life
-given anti-viral and anti-inflammatory
What are anti-HIV drugs for hep B virus?
Entercavir and Lamivudine, Adefovir
3 ways to prevent hepatitis B virus?
Passive immunization: given after you are infected -- HBVIG vaccine--> high tighter antibodies that neutralize the virus
Active immunization: give before you are infected--- HBV vaccine---> recombinant virus (EngeRix and TwinRix)
Perinatal congenital immunization: given both passive and active (HBVIG and HBV)
How do you diagnose Hepatitis D?
Presence of IgG antibodies to delta antigen in serum
treatment of hepatitis D?
there is no prevention or treatment of HDV but can be if there is a co-infection with HBV and given prophylaxis for it
Describe the etiology of HepC virus
-lack of proofreading to help escape immune response
-has 6 different genotypes and are curable
-has a flavivirus
-has hypervariable regions called E1 and E2 that help virus get into liver cells
is HepC virus self limiting?
no, it is chronic but curable
What are the risk factors with Hep C virus?
-large or repeated exposure to percutaneous exposure to blood
-IV drug user shared needles
-change needles not ink in tattoos
Sex or vertical transmission is low
What are the risk factors for hepatitis A?
working in a day care center and nursing home
closed populations with poor hygiene and sanitation (boarding school, summer camps)
-eating shellfish, oyster
transmission of Hep A?
primarily fecal-oral-virus is excreted in feces and enter new host via ingestion in food and water
is there a seasonality for hep a vaccine?
Is Hepatitis A self limiting
Other sets by this creator
GI module 3 part 5: Lynch
GI module 3 part 4: Viselli
GI module 3 part 3: Green
GI module 3
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