Cellular Adaptations, Cell Injury, and Cell Death
Terms and ides from Chapter 1 in Robbins Pathology.
What contributes to vacuolar degeneration of cells?
How does a hypoxic cell derive its energy?
Decreased pump capacity
Why does edema occur in hypoxic cells?
Is vacuolar degeneration reversible or irreversible cell damage?
Necrosis is always pathologic (True/false).
Apoptosis is always pathologic (True/false).
Decreased blood flow to a tissue
Decreased oxygen to a tissue
Which tissues are damaged more rapidly, ischemic or hypoxic?
Swollen mitochondria; swollen ER; pyknosis
List the characteristics of a cell in a state of reversible injury.
The type of necrosis dominated by denaturation
The type of necrosis characterized by dominant enzyme digestion.
Type of necrosis characterized by preserved cell outlines
Decreased cellular pH resulting in the denaturation of cellular enzymes occurs in this type of necrosis.
Necrosis characterized by focal bacterial or fungal infections
Dry gangrene is an example of this type of necrosis
A necrotic tissue (usually an extremity), originally ischemic, now infected with a bacteria
Necrosis characterized by amorphous granular debris enclosed within a distinct inflammatory border
Necrosis occurring during ischemia of CNS tissue
Fat destruction most often from pancreatic lipases.
Characterized by shadowy necrotic cell outlines with basophilic calcium deposits.
When necrotic tissue (any necrotic tissue) attracts Ca and other minerals, becoming calcified.
This element binds to the sulfhydryl groups of the cell membrane increasing membrane permeability and inhibiting ATPase-dependent transport
Compound that blocks oxidative phosphorylation by poisoning mitochondrial cytochrome oxidase
Compound metabolized by CYP450 into a reactive toxic radical species that attacks phospholipids, generating new radicals.
The dissociation of ribosomes from the rough ER leads to a decrease in apoprotein synthesis which is responsible for this morphologic change
A drug that is detoxified first by Cytochrome P450 (via sulfation and glucuronidation) and then by GSH. Toxicity results in hepatocellular necrosis
Type of cell death observed during embryogenesis.
Type of cell death observed in the endometrial cell during the menstrual cycle.
Cells with DNA damage are destroyed by this process.
Cell death associated with DNA ladder in agarose gel electrophoresis
Cell death associated with neutrophils
Cell death associated with macrophages
Cysteine proteases that inactivate DNases and break up nuclear scaffold and cytoskeleton.
A normally intracellular phospholipid, flipped extracellularly in an apoptotic cell
Tumor Necrosis Factor (TNF)
Family of membrane bound receptors that function in the extrinsic apoptotic pathway.
Death receptors are associated with this apoptotic pathway.
Anti-apoptotic protein normally found in mitochondrial membranes and cytoplasm..
Anti-apoptotic factors are sustained by this class of peptides
Apoptotic pathway controlled by the ratio of pro-apoptotic to anti-apoptotic molecules
Apoptotic pathway characterized by mitochondrial membrane permeability.
Tumor suppressor protein that accumulates when DNA is damaged. It stalls the cell cycle in G1 and can lead to apoptosis if its levels remain high.
Process of lysosomal digestion of material ingested from the extracellular environment.
Ingestion of apoptotic bodies by macrophages is an example of this type of lysosomal catabolism
The lysosomal digestion of the cell's own components
Undigested material derived from lipid peroxidation
Drug that inhibits lysosomal enzymes, reducing tissue damage in inflammatory reactions. Used to treat rheumatoid arthritis.
Organelle that will undergo hypertrophy when exposed to toxic chemicals (ethanol, barbituates) over an extended period of time.
Cellular site of cytochrome P450 detoxification.
Eosinophilic inculsion in liver cells, termed "alcoholic hyaline."
Mallory bodies are composed mainly of this intermediate filament and are characteristic of alcoholic liver disease.
Steatosis (fatty change)
An abnormal accumulation of triglycerides within parenchymal cells
The most common cause of significant fatty change in the liver in developed countries.
Decreased synthesis of apoproteins in the liver results in this type of change.
Intracellular hyaline change is attributed to the accumulation of what type of macromolecule.
Hyalinization of the walls of renal arterioles are an example of (intracellular/extracellular) hyaline change
Russell bodies and Mallory bodies are examples of (intracellular/extracellular) hyaline change.
Accumulation of exogenous carbon particles in the tracheobronchal lymph nodes resulting a blackening of the tissue.
Endogenous wear and tear pigment thought to be derived from lipid peroxidation.
Yellow-brown, finely granular intracytoplasmic pigment.
Endogenous brown-black pigment from the oxidation of dihydroxyphenylalanine
Hemoglobin derived golden to yellow-brown pigment. Seen where there is a local excess of iron.
Calcification always related to hypercalcemia secondary to disorder in calcium metabolism.
Local calcium deposition in dying tissues
Atherosclerosis is an example of which type of calcification.
Type of calcification found most often in tissues that have an internal alkaline compartment (lungs, kidneys, arteries, pulmonary veins and gastric mucosa)
With each replication this portion of the chromosome is thought to shorten eventually arresting the cell cycle.
The RNA-protein complex responsible for adding nucleotides onto the end of chromosomes using its own RNA template.
Active in cancers and germline cells, but inactive in normal somatic cells.