Swollen mitochondria; swollen ER; pyknosis
List the characteristics of a cell in a state of reversible injury.
Decreased cellular pH resulting in the denaturation of cellular enzymes occurs in this type of necrosis.
A necrotic tissue (usually an extremity), originally ischemic, now infected with a bacteria
Necrosis characterized by amorphous granular debris enclosed within a distinct inflammatory border
When necrotic tissue (any necrotic tissue) attracts Ca and other minerals, becoming calcified.
This element binds to the sulfhydryl groups of the cell membrane increasing membrane permeability and inhibiting ATPase-dependent transport
Compound that blocks oxidative phosphorylation by poisoning mitochondrial cytochrome oxidase
Compound metabolized by CYP450 into a reactive toxic radical species that attacks phospholipids, generating new radicals.
The dissociation of ribosomes from the rough ER leads to a decrease in apoprotein synthesis which is responsible for this morphologic change
A drug that is detoxified first by Cytochrome P450 (via sulfation and glucuronidation) and then by GSH. Toxicity results in hepatocellular necrosis
A normally intracellular phospholipid, flipped extracellularly in an apoptotic cell
Tumor Necrosis Factor (TNF)
Family of membrane bound receptors that function in the extrinsic apoptotic pathway.
Tumor suppressor protein that accumulates when DNA is damaged. It stalls the cell cycle in G1 and can lead to apoptosis if its levels remain high.
Ingestion of apoptotic bodies by macrophages is an example of this type of lysosomal catabolism
Drug that inhibits lysosomal enzymes, reducing tissue damage in inflammatory reactions. Used to treat rheumatoid arthritis.
Organelle that will undergo hypertrophy when exposed to toxic chemicals (ethanol, barbituates) over an extended period of time.
Mallory bodies are composed mainly of this intermediate filament and are characteristic of alcoholic liver disease.
The most common cause of significant fatty change in the liver in developed countries.
Intracellular hyaline change is attributed to the accumulation of what type of macromolecule.
Hyalinization of the walls of renal arterioles are an example of (intracellular/extracellular) hyaline change
Russell bodies and Mallory bodies are examples of (intracellular/extracellular) hyaline change.
Accumulation of exogenous carbon particles in the tracheobronchal lymph nodes resulting a blackening of the tissue.
Hemoglobin derived golden to yellow-brown pigment. Seen where there is a local excess of iron.
Calcification always related to hypercalcemia secondary to disorder in calcium metabolism.
Type of calcification found most often in tissues that have an internal alkaline compartment (lungs, kidneys, arteries, pulmonary veins and gastric mucosa)
With each replication this portion of the chromosome is thought to shorten eventually arresting the cell cycle.
The RNA-protein complex responsible for adding nucleotides onto the end of chromosomes using its own RNA template.