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Drugs Affecting Oxygenation Respiratory System

J1 semester only
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Repiratory center is the ...
medulla oblongata
Process of gas exchange is called
respiration
Process of ventilation is..
mechanical
V/Q ratio is ...
the amount of air reaching the alveoli to the amount of blood reaching the alveoli; should be about .95-1
Airway is the size of your ...
pinky
Inadequate ventilation/Oxygen means ....
increased airway resistance(swelling/mucus/ decreased ciliary action/bronchospasms)
Loss of elastic recoil of lungs(emphysema, cystic fibrosis)
Emphysema causes your alveoli to...
puff up, and become destroyed due to air being trapped and lung size increase
Pink puffers is a condition of...
emphysema
Asthma is also called...
airway reactive disorder
Asthma is either ...
intrinsic- non-allergic; infection or exercised induced
Extrinsic- allergy/hypersensitive; Ab/allergen rxn; mucus, swelling, bronchoconstriction
In an extrinsic rxn, Ab attach to ... cells, which rupture and release ..., and slow reacting substance of anaphylaxis(SRS-A)
mast;histamine
Drug administration for lung problems can be..
oral, IV, nasal spray, inhalant(Metered Dose Inhaler), inhalation
Inhaled drugs were known by ancient civilizations, current smokers, and drug abusers to...
act quickly, min. dose required, non-invasive
Scientists discovered that inhalants...
goes directly into lungs, min. side effects, avoids hepatic first pass, systemic absorbed
Metered dose inhalers are...
advantages: portable, cheap
Disadvantages: don't take it right
How you use inhalers is ....
shake, take deep breath while inhaling, wait 30 seconds, then rinse mouth(thrush/bacterial/yeast infection if don't)
Spacer is used if can't...
hold breath
What are the disadvantages/advantages of dry powder?
Advantages= no propellant, just inhale
Disadvantages= bulky, limited doses, expensive, don't know when you are out
Nebulizer's advantages/disadvantages are?
Advantages= for children/elderly/emrgency; drug nebulized into a mist; breath normally
Disadvantages=bulky, inconvenient, expensive, long tx time(10-15min), drug packaging varies, need power source
Antitussive is a ..
cough suppressant
Cough center is in the ...
medulla
Antitussive medicines..
depress cough center in medulla; cause post nasal drip
Some antitussive drugs are...
narcotics: codeine, hydrocodone; in tablets or syrup; cause drowsiness
Non-narcotics: dextromethorphan, Robutussin-DM, Benylin
Benzonatate(Tessalon) is similar to...Side effects are...
local anesthetic, anesthetizing stretch receptors in lungs(if receptors aren't stretch, then can't cough; rash, increased secretion, sedation, nausea, paradoxical excitement
Some long acting antitussive medications are...
whiskey+lemon+honey and wild cherry
Halls menthalarem cause ... because cause post nasal drip...
cough
Expectorant is....
sputum
Antitussive agents ...
promote the cough, or smoothing action on mucosa by increasing amount if liquid in repiratory tract (i.e Robutussin-stimulate secretions)
Antihistimines ....
dry you up; blocks effects of histamine(runny nose, congestion, allergic reaction, itching, motion sickness; side effects are sedation, dry mouth, urinary hesitency(anticholinergic)
Antihistimines also can cause an ....... attack, increase ..., increase blood pressure, and may trigger ... storm, increase ... pressure and photosensitivity, increase risk for seizures (avoid driving).
asthma;HR;Thyroid(too much); intraocular
Mucolytic's do what...
lysis tenacious secretion; some side effects are bronchospasms, smells like rotton eggs
Some mucolytic drugs are...
acetylcysteine-liquefies
Some nursing considerations of antitussives are...
adequate fluid intake(except milk); liquid cough medicine; Head above body when sleep; note color, consistency of sputum, avoid caffeine
Inflammatory cell(mast cell) stabilizer's ....
work on mast/macrophage/neutrophils/eosinophils cell's to prevent release of histamines; not antihistamines; give before exercising, running
Some Inflammatory cell stabilizer medicines are...
cromolyn sodium(Ital); have short half life
Antiinflammatory leukotriene receptor antagonist drugs are...
zafir lukast(accolate) or monte lukast (Singular); promotes bronchorelaxation, improves wheezing, coughing, dyspnea, decrease inflammation; slow acting and po; side effects are headache, nausea/vomiting
Corticosteroids...
decrease inflammation and edema; side effects are hoarseness, oral candida infection(suppress normal flora of mouth); must observe mouth for thrush
Some corticosteroid medications are
beclomethasone(Beclovert) and fluticasone propionate(Flonase), and prednisone given typically via inhalation and intranasal
Singular with inhaled steroid provides...
better control of inflammation becuase inhaled steroid can't formation of cysteinyl leukotrienes
Non-selective Bronchodilators are..
sympathamimic; epinephrine(potent);Vaponephrine(racemic epinephrine); Medhale-Epi; Primatine mist(OTC);Pseudoephedrine(sudafed)
Selective bronchodilators(Beta2 agonists) are...
albutrol(ventolin) po inhalation; metroproternol(Alupent) po inhalation; terbutaline(Brethine) po injection, inhalation[preterm labor relaxes bronch]; side effects are palpitation, tachycardia, headache, flushing, nausea, hypertension, anxiety, tremor
Anticholinergic bronchodilators are...
ipothropiaum bromide(atrovent); stops bronchoconstriction; side effects are glaucoma, cough, hoarseness, irritation, dry mouth, constipation, urinary retention, blurred vision, paradoxical effect
Bronchodilator Xanthine(caffeine) acts directly on .. muscle of bronchus and inhibits release of ...
smooth; SRS-A; (i.e. Theophylline by IV and Thoedor(sustained release); has narrow margin of safety of 10-20 ug/ml
Nursing considerations of bronchodilators...
initial therapy, stay with patient,quiet environment, upright position; percuss side and back to expel mucus plug then give aerosol; metered dose requires 2 puffs(wait 1min b/w puffs)