Manufactured by the tissue cells and secreted into body fluids.
depends on genes inherited for Lewis and inheritance of the Secretor gene.
genes influence the amount of Lewis antigen detected on the RBC.
substance is secreted regardless of secretorstatus. Even those who are sese, nonsecretors, willsecrete this Lewis substance into body fluids.
produced in body fluids are glycoproteins
Lewis RBC cell bound antigens
cell bound antigens are glycolipids.
Sese, ABO, Hh and Lewis genes
are all associated with the formation of the Leb antigen.
Le(a-b+) is 55%
-Generally produced by Le(a-b-) individuals and are frequently detected during antibody screening. -are considered naturally occurring since they appear without previous exposure to antigen positiveRBCs. -Normally are IgM
Most are IgM while some IgG does exists (doesn not fix complement) This antibody is generally not as common or as strong as Lea.
Lewis antigens (significant)
Lewis antigens have receptors to certain microorganisms like Helicobacter pylori
Le (a-b+) is 72%
LEa (a-b-) secretors express
H type 1 substances plus ABH antigens associated with the related ABO genes inherited.