Where do ducts open w/ pancreatic & liver secretions?
If you are missing this in colon, you would have megacolon?
In the liver, what does it mean if you have a lot of connective tissue?
sources of blood -> liver?
portal vein - 75% hepatic artery - 25%
in hepatic circulation, where does blood go toward?
Function of hepatocytes?
endocrine secretion -storage of lysosomes -degradation of toxins
Where are hepatic stellate cells? What is it a storage site for?
in space of disse - bw endothelial cells & microvilli of hepatocyte
aka ito cells
Where are kupffer cells? Main function?
Where are reticular fibers in liver?
walls of sinusoids
What can happen w/ ito cells?
transform to myofibroblasts & produce high level of collagen -collagen type 1 (cytokines produces by hepatocytes stimulate production) deposited in space of Disse leads to fibrosis & alteration of portal venous blood flow (portal hypertension)
Endocrine vs. exocrine liver
endo - secretion into sinusoids exo - secretion into bile canaliculi
How does liver cirrhosis occur?
progressive hepatocyte destruction due to alcohol toxicity, viral infection & liver disease -death of hepatocytes -> scarring -collapse of normal architecture & increased production of fibrocollagenous tissue (massive collagen production)
What are 3 ways of describing structure of liver? Most clinically important?