Bone cancer and related disease

A toddler comes in with fever, swelling and guarding of his thigh and cannot bear weight because of infection.
What part of the bone does it happen for kids and adult:
How does this present on X ray:
How does this present on histology:
Who do these bacteria affect:
Coagulase positive Staph (S. aureus)
Coagulase negative Staph (S. epidermidis, S. saphrophyticus)
Group B Strep (S. agalacticae)
H. influenza
Pseudomonas
Salmonella
Pasteurella
TB (how does this present on histolgoy. What special stain do you need)

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This is osteomyelitis
Metaphysis in kids and epiphysis in adults
X ray: necrosis in the centre, sclerotic bone surrounding it
Histology: neutrophils in the bone marrow space if acute.
S. aureus: most common in all ages
Coagulase negative: neonates in the ICU needing hemodialysis
Group B Strep: infants who are less than 3 months old
H. influenza: people who did not get flu shot
Psudomonas: IV drug user and diabetics
Salmonella: sickle cell
Pasteurella: bit by dog or cat
TB: Potts disease spread to vertebrae. You would see giant cells and gram cultures would be negative. Acid fast stain needed.

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Terms in this set (2)

- Describe sequestrum, involucrum and sinus tract in chronic osteomyelitis and why those happen.
- Histology of chronic osteomyelitis.
- Brodie's abscess in subacute osteomyelitis and Garre abscess.
- Cells in acute, subacute and chronic osteomyelitis

When chronic, the pus and neutrophils block the blood supply to the bone for which necrosis happens. The dead bone is the sequestrum and the sclerotic bone that forms around it is the involucrum.
Histology: fibrosis and mononuclear cells
sinus tract: drains pus from bone to skin
Brodie abscess: purulent collection surrounded by sclerosis in the bone. The purulent collection has neutrophils and mononuclear cells.
Garre abscess is osteomyelitis in the jaw.

- acute: neutrohpils
subacute: neutrophils and mononuclear cells
chronic: fibrosis