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Terms in this set (34)
Is it possible to personalize cancer therapy?
Yes, by sequencing the genome of tumor cells and tailoring the treatment based on the tumor's specific genetic profile
Which type of tumor is cancerous?
Process by which malignant tumors spread to other locations
Can spread to other locations in a process called metastasis
Remains at the original site but may disrupt certain organs if it grows in size
A mass of abnormally growing cells within otherwise normal tissue
Cancer and cell cycle
Cancer cells escape controls on the cell cycle
Allows entry into the S phase or causes the cell to leave the cycle, entering a nondividing G0 phase
Cell cycle control system
Cycling set of molecules in the cell that triggers and coordinates key events in the cell cycle
Cell division is controlled by
Anchorage dependence, density-dependent inhibition, the presence of essential nutrients, and growth factors
Crowded cells stop dividing
The need for cells to be in contact with a solid surface to divide
Proteins that stimulate division
Checkpoints in the cell cycle can either...
Stop an event or signal an event to proceed
Three major checkpoints in the cell cycle
G1, G2, M
Localized tumors can be...
Moved surgically and/or treated with radiation
Metastatic tumors are treated with...
How many cancer cells have been identified?
How many oncogenes have been identified?
How many tumor suppressor genes have been identified?
Normally stimulate growth
Accelerate cell growth (like an accelerator in a car)
Tumor suppressor genes
Normally inhibit growth
Mutated tumor suppressor genes
Cause cell cycle to produce more quickly (like the broken brake of a car)
Can become an oncogene that causes cancer
How many cell growth and survival genes are there?
How many genome maintenance genes are there?
How many cell fate genes are there?
P53 is a...
Tumor suppressor gene (you need to lose both copies of the gene to get cancer)
Cyclin is an....
Cell growth and survival
Proto-oncogenes and genes that regulate the cell cycle
"Repair" genes that limit mutations (they proofread)
If there is a mutatoin in a proofreading enzyme...
Mutations accumulate rapidly
Mutations in these genes can block a stem cell from differentiating into mature cells, causing a pile-up of cells
THIS SET IS OFTEN IN FOLDERS WITH...
Nature of Science Unit Test
Cell Parts Functions
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