A maladaptive pattern of substance use, leading to clinically significant impairment or distress, as manifested by 3 or more of the following 7 criteria: tolerance, withdrawal, increased dose or dosing for longer periods of time, attempts to cut down unsuccessfully, time spent obtaining, using, recovering from use, important social, occupational and recreational activities given up or reduced because of use, physical or psychological problems caused or exacerbated by continued use.