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TLR Quiz

Terms in this set (20)

MyD88s and IRAK-M downregulate signalling through TLRs
A. True
B. False
true
Toll-like receptors (TLRs):
A. were first discovered in fruit flies
B. in German it means 'great'
C. mutations of these receptors made fruit flies susceptible to fungal infections
D. all of the above
all of the above
Endotoxin (LPS) is comprised of:
A. a lipid component
B. a saccharide component
C. a phosphate component
D. all of the above
all of the above
All TLRs are found on the exterior plasma membrane
A. True
B. False
false
Some TLR receptors bind:
A. lipopolysaccharide
B. flagellin
C. IL-10
D. A & B
E. all of the above
lipopolysaccharide and flagellin
MyD88 interacts with:
A. Iκκ
B. TAK1
C. TAB1
D. none of the above
none of the above
TLR3, TLR7, and TLR8 bind viral nucleic acids
A. True
B. False
true
Gram negative bacteria express:
A. endotoxin (LPS)
B. ssRNA
C. dsRNA
D. none of the above
endotoxin (LPS)
MyD88 knock out mice:
A. do not produce TNF-α
B. exhibit delayed response to LPS
C. exhibit no response to LPS
D. A &B
E. B & C
do not produce TNF-α and exhibit delayed response to LPS
Poly I:C is a synthetic double stranded nucleic acid homologue frequently used to stimulate TLR9 receptors
A. True
B. False
false
High levels of LPS can cause septic shock
A. True
B. False
true
Early onset inflammatory cytokines transciption typically involves:
A. TRAF6
B. MyD88
C. Iκκ
D. all of the above
all of the above
MyD88s downregulate the inflammatory response while MyD88 upregulates it
A. True
B. False
true
Which of the following is NOT a TLR ligand?
A. single stranded RNA
B. double stranded RNA
C. CpG
D. LDL
LDL
The role of IκB is to:
A. prohibit NFκB from moving to the nucleus
B. facilitate NFκB to translocate to the nucleus
C. activate Iκκ
D. none of the above
prohibit NFKB from moving to the nucleus
Which of the following TLRs are localized in the internal compartment of cells?
A. TLR3
B. TLR7
C. TLR9
D. all of the above
all of the above
Which of the following TLRs have signalling pathways that do NOT involve MyD88?
A. TLR4
B. TLR3
C. TLR2
D. A & B
E. A & C
TLR4 and TLR3
Activated TAK1:
A. activates IκB
B. activates Iκκ
C. activates IRAK-M
D. none of the above
activates IKK
The exterior domain of TLRs is rich in:
A. histidine repeats
B. leucine repeats
C. tryptophan repeats
D. none of the above
leucine repeats
Map kinases can be activated by TAK1
A. True
B. False
true
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