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Acute phase reactants
Terms in this set (11)
What is ESR?
Erythrocyte sedimentation rate
Old, well-established acute phase reactant
Measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood (measured in mm/hr)
Primarily affected by fibrinogen
What is CRP?
Acute phase protein synthesized by the liver
Part of the innate immune system
5 positive acute phase reactants (apart from CRP and ESR)
Procalcitonin (specific for infection)
3 negative acute phase reactants
What are the advantages of ESR?
Cheaper (therefore more widely available)
What are the advantages of CRP?
More responsive to changes in inflammatory state
What are 2 conditions that elevate ESR in the absence of an inflammatory state?
What are 2 conditions that depress ESR?
Polycythaemia rubra vera
What are the 4 conditions that must be considered in a patient with an extremely elevated ESR (>100)?
Malignancy (particularly multiple myeloma)
Renal conditions (end-stage renal failure, nephrotic syndrome)
Inflammatory disorders (particularly temporal arteritis/polymyalgia rheumatica)
What is the most common cause of elevated CRP?
Which conditions is ESR useful in the diagnosis of?