Upgrade to remove ads
Acute phase reactants
Terms in this set (11)
What is ESR?
Erythrocyte sedimentation rate
Old, well-established acute phase reactant
Measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood (measured in mm/hr)
Primarily affected by fibrinogen
What is CRP?
Acute phase protein synthesized by the liver
Part of the innate immune system
5 positive acute phase reactants (apart from CRP and ESR)
Procalcitonin (specific for infection)
3 negative acute phase reactants
What are the advantages of ESR?
Cheaper (therefore more widely available)
What are the advantages of CRP?
More responsive to changes in inflammatory state
What are 2 conditions that elevate ESR in the absence of an inflammatory state?
What are 2 conditions that depress ESR?
Polycythaemia rubra vera
What are the 4 conditions that must be considered in a patient with an extremely elevated ESR (>100)?
Malignancy (particularly multiple myeloma)
Renal conditions (end-stage renal failure, nephrotic syndrome)
Inflammatory disorders (particularly temporal arteritis/polymyalgia rheumatica)
What is the most common cause of elevated CRP?
Which conditions is ESR useful in the diagnosis of?
THIS SET IS OFTEN IN FOLDERS WITH...
Fever in returned traveller/ malaria
YOU MIGHT ALSO LIKE...
Ch 25 - Burns - Acute Phase
Drug Cards Units 21, 22, 15, 16, 17, 23, 24, 25
Acute and Chronic Renal Disease
Acute Kidney Injury
OTHER SETS BY THIS CREATOR
Primary Billiary Cholangitis
Medication management in AKI