Terms in this set (24)
In Cocaine, _____ will be rapidly hydrolyzed which is why it has short DoA
All LA have which 3 portions with the exception of Benzocaine
Hydrophilic, Lipophilic, and Intermediate
What is the hydrophilic portion of LAs?
What is the lipophilic portion of LAs?
What is the intermediate portion of LAs?
Ester or Amide
Which intermediate portion extends the DoA
Benzocaine lacks which portion?
Anesthetics block _____ conductance
LAs act mainly by blocking _____ channel function
LAs do not interact with pain receptors or inhibit the release/biosynthesis of _____
Inactivation of the sodium channel occurs at which linker?
III-IV linker ("h" gate)
Recovery of the membrane potential results from?
Inactivation of sodium channels and delayed opening of VG K Channels causing repolarization
LAs may reduce membrane excitability by?
Blocking Na channels or activating potassium
Drugs may enhance membrane excitability by?
Block inactivation of sodium channels or potassium channels
Stereochemistry of LAs plays a role in _____ and _____ properties
Toxicity and PK
LAs block ______ generated by blocking sodium channels
LAs block conduction in the following order:
Small myelinated axons, non-myelinated axons, Big myelinated axons
Unwanted side effects of LAs generally result from escape into __________
What is a CV side effect of LA use?
Drop in blood pressure
CNS side effects of LA use?
Agitation, confusion, tremors, respiratory depression
Characteristics of the ideal LA
Rapid onset, sufficient DoA, minimal irritation and systemic toxicity, reversible blockage of sensory nerve fibers with minimal on motor fibers
______ is produced by a marine bacterium and accumulates in the tissue of the puffer fish
______ is produced by a marine microorganism and can proliferate in large numbers giving the "Red tide" phenomenon
Both TTX and STX act exclusively from outside the _______
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