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adhere to damaged capillary wall and underlying collagen fibers, both of which have a negative charge
stage 1 of blood clotting
production of thromboplastin activator by having chemicals present in the blood (intrinsic pathway)
doesn't contain ribosomes, mitochondria, and other organelles typical of most body cells
In RBCs, this catalyzes a reaction that joins carbon dioxide and water to form carbonic acid
ions generated by the dissociation of acid and generation of H+, which diffuses out of the RBCs and into the blood plasma
hematopoietic stem cells
nucleated cells in the adult where erythrocytes begin their maturation sequence in the red bone marrow
normally, every mintue of every day of our adult lives, more than 200 billion of these cells are formed to replace an equal number destroyed during that brief time
mechanisms that must operate to balance the number of cells formed against the number destroyed
phagocytosing of the aged, abnormal, or fragmented RBCs
this process results in the breakdown of hemoglobin, with the release of amino acids, iron, and bilirubin
granulocyte with numbers avergaing about 65% of the total WBC count in a normal blood sample
weak phagocytes that are capable of ingesting inflammatory chemicals and proteins associated with antigen-antibody reaction complexes.
aid in protection against infections caused by parasitic worms and involvement in allergic reactions
the smallest of all leukocytes and next to neutrophils, these are the most numerous WBCs
one cubic millimeter of normal blood usually contains about ____ to ________ leukocytes, with different percentages of each type
neutrophils, eosinophils, basophils, and a few lymphocytes and monocytes
cells that originate in red bone marrow
most lymphocytes and monocytes
cells that derive from hematopoietic adult stem cells in lymphatic tissue
in circulating blood, these are small, nearly colorless bodies that usually appear as irregular spindles or oval disks
hemostatic platelet plug
formed within 1-5 seconds after injury to a blood capillary; platelets will adhere to the damaged lining of the vessel and to each other in order to form this structure
can appear in the blood of an Rh-negative person, provided Rh-positive RBC's have at some time entered the bloodstream
to plug ruptured vessels to stop bleeding and prevent loss of a vital body
primary purpose of blood coagulation
oppose (inactivate) thrombin & prevent thrombin from converting fibrinogen to fibrin ; ex: heprin
two conditions that favor thrombus function
a rough spot in the endothelium & abnormally slow blood flow
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