79 terms

Organ Systems Exam 5 Pharm

Pharmacology relating to Diabetes, Lipidemia, GI, Endocrine
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Psyllium
Fiber-like Laxative
Magnesium Hydroxide
Osmotic Lax 1-3hrs
MgSo4
Osmotic Lax 1-3hrs
Sorbital
Osmotic Lax 1-3hrs
Phenolphthalein
Stim Lax 6-8hrs
Bisacodyl
Stim Lax 6-8hrs
Senna
Stim Lax 6-8hrs
Castor Oil
Stim Lax 6-8hrs
Docusate
Stim Lax 1-3hrs
Cisapride
Serotonin 5HT4 Agonist-promote GI motility, decrease acid reflux, diabetic gastroporesis, chronic constipation
Dicyclomine
Anti-diarrheal, Anti-musc,
Diphenoxylate
Anti-diarrheal
Can cross BBB, Opoid agonist
Loperamide
Anti-diarrheal,Toxic megacolon
CANNOT cross BBB, Opoid agonist
Syrup of Ipecac
Anti-emesis
directly affects CTZ (cardiotoxic, myopathy)
Ondansetron
Anti-emesis
serotonin HT3 antagonist (use with glucocorticoids)
Metoclopramide
Anti-emesis, N/V, GERD, diabetic gastroporesis
D2 receptor antatgonist/agonist @ 5HT4 (increase upper GI motility)
Promethazine
Anti-emesis, H1/M receptors
Prochlorperazine
D2/M/H1/5HT
Anti-emesis, antipsychotic
Scopolamine
motion sickness, most efficacious
Diphenhydramine
motion sickness
Dimenhydrinate
motion sickness
Promethazine
motion sickness
Meclizine
motion sickness-less sedative
Budesonide
IBD
Prednisone
IBD
Prednisolone
IBD
5-ASA
IBD, anti-inflammatory
ACTIVE
Sulfasalatine
IBD-Degrades into 5-ASA
Balsalazide
IBD-Degrades into 5-ASA
Mesalamine
IBD-Degrades into 5-ASA
Infliximab
IBD-TNFalpha Ab
Cromolyn Sodium
IBD-prevents act. of mast cells, ulcerative colitis
Prednisone
glucocorticoid for hypoadrenalism, must use with mineralcorticoid
Prednisolone
glucocorticoid for hypoadrenalism, must use with mineralcorticoid
Triamcinolone
glucoc for hypoadrenalism-Asthma
Acetomide
glucoc for hypoadrenalism-Asthma
Betamethasone
glucoc for hypoadrenalism-No salt retention
Dexamethasone
glucoc for hypoadrenalism-No salt retention
Fludocortisone
Most commonly prescribed mineralcorticoid
for hypoadrenalism
Metyrapone
Anti-adrenalcorticoid-inhibits 11-beta-hydrox
Aminoglutethimide
Anti-adrenalcorticoid-inhibits first step
Mifepristone
Anti-adrenalcorticoid-binds to progesterone and glucocorticoid receptors
Spirolactone
Anti-adrenalcorticoid-binds to mineralcorticoids and androgen receptors
Eplerenone
Anti-adrenalcorticoid-aldo antagonist
EDTA
Lead/Mercury antagonist-MUST BE taken with Ca or else heart will stop and hypotenstion
Dimercaporl
Lead/Mercury/Arsenic antagonist-can cause HTN and tachycardia
Succimer
Lead/Mercury/Arsenic antagonist-fewer side effects
Deferoxamine
competes with loosely bound iron
Penicllamine
copper antagonist
sodium nitrate
cyanide poisoning-metheme
sodium thiosulfate
cyanide poisoning-thiocyanate
hydroxycobalamine
cyanide poisoning-b12
Omeprazole
PPI
cimetidine
H2 blocker "take h2 blockers before you Dine think table for 2"
Bismuth, sucralfate
bind to ulcer base, providing physical protection (Peptobismol)
Misoprostol
PGE1 analog
increase mucus, decrease acid
Tetracycline, Metronidazole
Tx of ulcers-H.pylori
Mg(OH)2
Antacid-diarrhea, don't use with Ab, alkalize blood/urine
Al(OH)3
Antacid-diarrhea, don't use with Ab, alkalize blood/urine
Statins
competitive inhibitors of HMG-CoA reductase
fluvastatin
100% absorption (hepatotoxicity, myopathy), don't use with gemfibrozil
rosuvastatin
19hr half life (hepatotoxicity, myopathy), don't use with gemfibrozil
Colestipol
bile acid sequestering resin-for primary hypercholesterolemia, no effect on familial
cholestryamine
bile acid sequestering resin-for primary hypercholesterolemia, no effect on familial
colesevelam
bile acid sequestering resin-for primary hypercholesterolemia, no effect on familial
ezetimibe
an inhibitor of cholesterol absorption by enterocytes in the small intestine
Niacin
oldest antilipemic
fibrates
interact with PPAR, induces perixsomal proliferation
gemfibrozil
fibrates
fenofibrate
fibrates
levothyroxine
t4 precise dosing, hypoallergenic, one daily
liothyronine
t3
more active
cardiotoxic, multiple dosing
liotrix
ratio of t3t4
propylthioruacil
treatment of hyperthyroidism, inhibit thyroid peroxidase, block iodination, block iodotyrosine coupling, block deiodination of t4 to t3, does NOT block release
Liver failure, agranulocytosis
methimazole
treatment of hyperthyroidism, inhibit thyroid peroxidase, block iodination, block iodotyrosine coupling, block deiodination of t4 to t3, does NOT block release
thiocyanate
blocks uptake of iodide
perchlorate
blocks uptake of iodide
iodine
inhibits TH synthesis and release
radioactive iodine
necrosis of follicle cells